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Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

2019Journal article Open access
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dc.contributor.authorFerrari, Fiorenza
dc.contributor.authorPuci, Mariangela Valentina
dc.contributor.authorFerraro, Ottavia Eleonora
dc.contributor.authorRomero-González, Gregorio
dc.contributor.authorHusain-Syed, Faeq
dc.contributor.authorRizo-Topete, Lilia
dc.contributor.authorSenzolo, Mara
dc.contributor.authorLorenzin, Anna
dc.contributor.authorMuraro, Eva
dc.contributor.authorBaracca, Antonio
dc.contributor.authorSerrano-Soto, Mara
dc.contributor.authorMolano Triviño, Alejandra
dc.contributor.authorCastro, Ana
dc.contributor.authorDe Cal, Massimo
dc.contributor.authorCorradi, Valentina
dc.contributor.authorBrendolan, Alessandra
dc.contributor.authorScarpa, Marta
dc.contributor.authorCarta, Maria Rosa
dc.contributor.authorGiavarina, Davide
dc.contributor.authorBonato, Raffaele
dc.contributor.authorIotti, Giorgio Antonio
dc.contributor.authorRonco, Claudio
dc.date.accessioned2020-08-21T11:56:41Z
dc.date.available2020-08-21T11:56:41Z
dc.date.issued2019
dc.description.abstractAKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerrari F, Puci MV, Ferraro OE, et al. Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit. PLoS One. 2019;14(6):e0217424. Published 2019 Jun 20. doi:10.1371/journal.pone.0217424pt_PT
dc.identifier.doi10.1371/journal.pone.0217424pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.16/2439
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217424pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIntensive Care Unitspt_PT
dc.titleDevelopment and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unitpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPagee0217424pt_PT
oaire.citation.titlePloS onept_PT
oaire.citation.volume14pt_PT
person.familyNameFerrari
person.familyNameCastro
person.givenNameFiorenza
person.givenNameAna
person.identifier.ciencia-idC012-7D92-E4A3
person.identifier.orcid0000-0001-6001-7072
person.identifier.orcid0000-0001-8328-2805
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7bee45a7-5ba0-432e-9ea2-39ddb9bbcc57
relation.isAuthorOfPublication84cd7cbf-1683-4893-a73a-da16a8a4cdd3
relation.isAuthorOfPublication.latestForDiscovery84cd7cbf-1683-4893-a73a-da16a8a4cdd3

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