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Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study

2019-02Journal article Open access
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dc.contributor.authorSerrão, R.
dc.contributor.authorPiñero, C.
dc.contributor.authorVelez, J.
dc.contributor.authorCoutinho, D.
dc.contributor.authorMaltez, F.
dc.contributor.authorLino, S.
dc.contributor.authorSarmento E Castro, R.
dc.contributor.authorTavares, A.
dc.contributor.authorPacheco, P.
dc.contributor.authorLopes, M.
dc.contributor.authorMansinho, K.
dc.contributor.authorMiranda, A.
dc.contributor.authorNeves, I.
dc.contributor.authorCorreia de Abreu, R.
dc.contributor.authorAlmeida, J.
dc.contributor.authorPássaro, L.
dc.date.accessioned2020-05-14T15:23:18Z
dc.date.available2020-05-14T15:23:18Z
dc.date.issued2019-02
dc.description.abstractObjective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. Results: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). Conclusions: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.pt_PT
dc.description.sponsorshipMerck Sharp & Dohme, Lda, Portugal provided financial support for the non-interventional study (Protocol Nr. MK0518-826 ).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSerrão R, Piñero C, Velez J, et al. Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study. Int J Infect Dis. 2019;79:94‐100. doi:10.1016/j.ijid.2018.10.011pt_PT
dc.identifier.doi10.1016/j.ijid.2018.10.011pt_PT
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.urihttp://hdl.handle.net/10400.16/2391
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.ijidonline.com/article/S1201-9712(18)34557-0/fulltextpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAgingpt_PT
dc.subjectHIV-1 infectionpt_PT
dc.subjectNon-AIDS comorbiditiesspt_PT
dc.titleNon-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCanadapt_PT
oaire.citation.endPage100pt_PT
oaire.citation.startPage94pt_PT
oaire.citation.titleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseasespt_PT
oaire.citation.volume79pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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