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Clinical Usefulness of Streptococcus pneumoniae Urinary Antigen in Patients Hospitalized with Non-Nosocomial Pneumonia

2012Journal article Open access
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dc.contributor.authorFerreira, J.
dc.contributor.authorAbreu, M.
dc.contributor.authorRodrigues, P.
dc.contributor.authorMaia, J.
dc.contributor.authorLeuschner, P.
dc.contributor.authorCorreia, J.
dc.date.accessioned2012-08-08T09:53:38Z
dc.date.available2012-08-08T09:53:38Z
dc.date.issued2012
dc.description.abstractIntroduction : Community acquired pneumonia (CAP) is a major cause of hospital admissions and mortality in developed countries. Nevertheless, in about half of the cases a microbial etiology can`t be determined. The need to improve the diagnostic tools of this disease has led to the development of new techniques, such as Streptococcus pneumoniae urinary antigen. Objectives : To analyse the usefulness of the urinary antigen in determining the etiologic diagnosis of pneumonias and its influence in the antibiotherapy modification. Methods : Retrospective analysis of hospitalized patients in 2010 with CAP (n=226) and healthcare associated pneumonia (HCAP) [n=64] diagnosis whose urinary pneumococcal antigen has been analyzed. Results: Median age was significantly greater in HCAP. HCAP patients had more co-morbidities and higher severity scores. Twenty-one patients in the CAP group and 4 patients in the HCAP group had positive pneumococcal antigen. The sensibility of urinary antigen in determining pneumococcal pneumonias was 36% and the specificity 89%. Almost one quarter of the 25 patients with positive urinary antigen had appropriate reductions in antimicrobial spectra, which was not statistically significant when compared with the group with negative urinary antigen. There was a significant relation between a positive urinary antigen and pneumonia severity. Conclusions: Considering its high specificity, the urinary antigen is useful to confirm the presence of pneumococcal pneumonia. Potentially urinary antigen can help to avoid unnecessary treatments in hospitalized patients with CAP.por
dc.identifier.citation2012 Volume 9 Number 2.por
dc.identifier.otherDOI: 10.5580/2bd6
dc.identifier.urihttp://hdl.handle.net/10400.16/1273
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherThe Internet Journal of Internal Medicinepor
dc.relation.publisherversionhttp://www.ispub.com/journal/the-internet-journal-of-internal-medicine/volume-9-number-2/clinical-usefulness-of-streptococcus-pneumoniae-urinary-antigen-in-patients-hospitalized-with-non-nosocomial-pneumonia.htmlpor
dc.subjectpneumoniapor
dc.subjectStreptococcus pneumoniae urinary antigenpor
dc.subjectclinical usefulnesspor
dc.titleClinical Usefulness of Streptococcus pneumoniae Urinary Antigen in Patients Hospitalized with Non-Nosocomial Pneumoniapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleThe Internet Journal of Internal Medicinepor
oaire.citation.volume9por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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