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Perianal Paget Disease: Different Entities With the Same Name

2021-05Journal article Open access
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dc.contributor.authorSantos, Marisa D.
dc.contributor.authorSoares, Filomena
dc.contributor.authorPresa-Fernandes, José M
dc.contributor.authorSilva, Donzília Sousa
dc.date.accessioned2023-12-18T16:55:13Z
dc.date.available2023-12-18T16:55:13Z
dc.date.issued2021-05
dc.description.abstractExtramammary Paget disease (EMPD) is a rare form of cancer that involves skin areas rich in apocrine glands. The common sites of occurrence include the vulva, perianal region, perineum, and axilla. Perianal Paget disease (PPD) is a subset of EMPD, which arises in the perianal skin. The disease commonly presents with a thickened plaque-like lesion with erythema or white scaly appearance. It is generally classified into two categories based on the origin of the tumor cells: (1) primary PPD if the tumor arises from intraepidermal cells and (2) secondary PPD if cancer originates from the underlying colorectal or urinary tract neoplasm. Due to its rarity, only a few sporadic case reports have been published in the literature, and treatment methods are yet to be standardized. In light of this, we report two PPD cases with different etiopathogenesis and staging: one involved only the perianal skin without regional or metastatic disease, and was not accompanied by visceral adenocarcinomas although there was a previous history of sigmoid adenocarcinoma; the other was probably secondary to an anal canal tumor spreading with disseminated disease involving the perianal and perineum area with bilateral inguinal, pelvic lymph node, and liver metastasis. The treatment plans and the outcomes of both cases were necessarily different from each other.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos MD, Soares F, Presa-Fernandes JM, Silva DS. Perianal Paget Disease: Different Entities With the Same Name. Cureus. 2021;13(5):e15161. doi:10.7759/cureus.15161pt_PT
dc.identifier.doi10.7759/cureus.15161pt_PT
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.16/2894
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCureus, Inc.pt_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/56924-perianal-paget-disease-different-entities-with-the-same-name#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectextramammary paget’s diseasept_PT
dc.subjectperianal paget’s diseasept_PT
dc.subjectsurgery in perianal paget´s diseasept_PT
dc.titlePerianal Paget Disease: Different Entities With the Same Namept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage15161pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume13pt_PT
person.familyNameSantos
person.familyNameSousa Silva
person.givenNameMarisa Domingues
person.givenNameDonzília
person.identifier.ciencia-id2614-4776-FCC3
person.identifier.orcid0000-0002-5704-8895
person.identifier.orcid0000-0002-7165-3581
person.identifier.scopus-author-id28167917200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication72eb66c1-42ee-4d4f-bae4-5ae939f1e1c9
relation.isAuthorOfPublication34ecdfec-215c-4190-8a44-6243e002c008
relation.isAuthorOfPublication.latestForDiscovery72eb66c1-42ee-4d4f-bae4-5ae939f1e1c9

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