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Impact of Homocysteinemia on Long-Term Renal Transplant Survival

dc.contributor.authorFonseca, Isabel
dc.contributor.authorMartins, La Salete
dc.contributor.authorQueirós, J.
dc.contributor.authorMendonça, D.
dc.contributor.authorDias, L.
dc.contributor.authorSarmento, A.M.
dc.contributor.authorHenriques, A.C.
dc.contributor.authorCabrita, A.
dc.date.accessioned2010-06-09T11:07:29Z
dc.date.available2010-06-09T11:07:29Z
dc.date.issued2005-07
dc.description.abstractImpact of Homocysteinemia on Long-Term Renal Transplant Survival I. Fonseca, L. Martins, J. Queirós, D. Mendonça, L. Dias, A.M. Sarmento, A.C. Henriques, and A. Cabrita ABSTRACT Aim. We prospectively followed cohort of 202 renal transplant recipients for years to examine the impact of fasting homocysteinemia on long-term patient and renal allograft survival. Methods. Cox proportional hazards regression analysis was used to identify independent predictors of all-cause mortality and graft loss. Results. Hyperhomocysteinemia (tHcy 15 mol/L) was present in 48.7% of the 202 patients, predominantly among men (55.8%as opposed to women (37.1%)At the end of the follow-up period, 13 (6.4%patients had died including 10 from cardiovascular disease, and 23 had (11.4%had lost their grafts. Patient death with functioning allograft was the most prevalent cause of graft loss (13 recipients)Levels of tHcy were higher among patients who died than among survivors (median 23.9 vs 14.3 mol/L; .005)Median tHcy concentration was also higher among the patients who had lost their allografts than those who did not (median 19.0 vs 14.1 mol/L; .001)In Cox regression model including gender, serum creatinine concentration, transplant duration, traditional cardio- vascular risk factors, and associated conditions, such as past cardiovascular disease, only tHcy concentration (ln) (HR 5.50; 95% CI, 1.56 to 19.36; .008) and age at transplantation (HR 1.07; 95% CI, 1.02 to 1.13; .01) were independent predictors of patient survival. After censoring data for patient death, tHcy concentration was not risk factor for graft loss. Conclusions. This prospective study shows that tHcy concentration is significant predictor of mortality, but not of graft loss, after censoring data for patient death.pt
dc.identifier.urihttp://hdl.handle.net/10400.16/273
dc.language.isopor
dc.publisherTransplantation Proceedingspt
dc.titleImpact of Homocysteinemia on Long-Term Renal Transplant Survivalpt
dc.typejournal article
dspace.entity.typePublication
person.familyNameFonseca
person.familyNameMartins
person.givenNameIsabel
person.givenNameLa Salete
person.identifier415128
person.identifier1911437
person.identifier.ciencia-id6716-A5D1-FB3F
person.identifier.ciencia-id7A1B-8631-FC46
person.identifier.orcid0000-0001-8984-1751
person.identifier.orcid0000-0002-6110-2102
person.identifier.ridK-6339-2013
person.identifier.scopus-author-id55941495000
person.identifier.scopus-author-id56207848700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept
relation.isAuthorOfPublication2c7a2607-6376-486e-9ad5-490d0032946c
relation.isAuthorOfPublication71fef9db-e03d-423a-af46-2909891b037d
relation.isAuthorOfPublication.latestForDiscovery2c7a2607-6376-486e-9ad5-490d0032946c

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