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Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction

2021-06Journal article Open access
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dc.contributor.authorMarta, Ana
dc.contributor.authorBaptista, Pedro Manuel
dc.contributor.authorMarques, Joao Heitor
dc.contributor.authorAlmeida, Daniel
dc.contributor.authorJosé, Diana
dc.contributor.authorSousa, Paulo
dc.contributor.authorBarbosa, Irene
dc.date.accessioned2023-10-19T11:49:36Z
dc.date.available2023-10-19T11:49:36Z
dc.date.issued2021-06
dc.description.abstractPurpose: To analyse the clinical outcome in patients with meibomian gland dysfunction (MGD) who underwent intense pulsed light (IPL) plus low-level light therapy (LLL). Materials and methods: The prospective non-comparative study included identified by MGD patients with altered interferometry and lower loss area of the meibomian glands (LAMG), who underwent IPL plus LLL, between July 2020 and August 2020. A multimodal assessment was performed before, 2-3 weeks, and 6 months after treatment. The main outcome was lipid layer thickness (LLT) and the secondary outcomes were the ocular surface disease index (OSDI) score, presence of corneal fluorescein staining (CFS), blink rate (BR), Schirmer test (ST), tear meniscus height (TMH), tear osmolarity (OSM), non-invasive break-up time (NIBUT) and LAMG. Results: This study included 62 eyes of 31 patients, 61.3% female, with a mean age of 66.94±9.08 years at the time of IPL plus LLL treatment. LLT (<0.001) grades improved 6 months after treatment. The mean OSDI score improved (p<0.001) from 45.02±21.17 (severe symptoms) to 22.35±17.68 (moderate symptoms) at 2-3 weeks and 8.24±17.9.91 (normal) at 6 months after treatment. CFS was identified in 51.6% (32/62) before and in 45.2% (28/62) 6 months (p=0.293) after treatment. ST (p=0.014) grades improved; OSM grades mild worsened (p<0.001); TMH, NIBUT and LAMG grades did not modify 6 months after treatment. No patient suffered any adverse effects. Conclusion: IPL combined with LLL was effective and safe, improving the lipid layer thickness in MGD and decreasing the level of symptoms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarta A, Baptista PM, Heitor Marques J, et al. Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction. Clin Ophthalmol. 2021;15:2803-2811. doi:10.2147/OPTH.S318885pt_PT
dc.identifier.doi10.2147/OPTH.S318885pt_PT
dc.identifier.issn1177-5467
dc.identifier.issn1177-5483
dc.identifier.urihttp://hdl.handle.net/10400.16/2827
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/intense-pulsed-plus-low-level-light-therapy-in-meibomian-gland-dysfunc-peer-reviewed-fulltext-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectOSDIpt_PT
dc.subjectdry eye diseasept_PT
dc.subjectintense pulsed lightpt_PT
dc.subjectevel low light treatmentpt_PT
dc.subjectlipid layer thicknesspt_PT
dc.subjectmeibomian gland dysfunctionpt_PT
dc.titleIntense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage2811pt_PT
oaire.citation.startPage2803pt_PT
oaire.citation.titleClinical Ophthalmologypt_PT
oaire.citation.volumeVolume 15pt_PT
person.familyNameMarta
person.familyNameBaptista
person.familyNameMarques
person.familyNameJosé
person.familyNameBarbosa
person.givenNameAna
person.givenNamePedro Manuel
person.givenNameJoao Heitor
person.givenNameDiana
person.givenNameIrene
person.identifier.orcid0000-0003-3495-4649
person.identifier.orcid0000-0001-8285-1084
person.identifier.orcid0000-0001-6487-7950
person.identifier.orcid0000-0002-8415-0780
person.identifier.orcid0000-0001-6053-5339
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication27861687-928c-4618-9f11-92d74ec326e0
relation.isAuthorOfPublicationaefa59ff-77f9-42ff-ac9b-88373f5c2ac8
relation.isAuthorOfPublicationb1e9a3af-258b-4e7c-9ea6-bb2f67e31bfd
relation.isAuthorOfPublication82af911d-7ad4-45a9-9d96-bdbf43ed20ce
relation.isAuthorOfPublication0794e8b1-dfb3-41a9-84aa-29915b10c531
relation.isAuthorOfPublication.latestForDiscovery27861687-928c-4618-9f11-92d74ec326e0

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