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Pretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Study

2021-07Journal article Open access
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dc.contributor.authorVentura, Eduardo
dc.contributor.authorBarros, João
dc.contributor.authorSalgado, Inês
dc.contributor.authorMillán, Ana
dc.contributor.authorVilares, Miguel
dc.contributor.authorZagalo, Carlos
dc.contributor.authorGomes, Pedro
dc.date.accessioned2023-12-18T17:00:14Z
dc.date.available2023-12-18T17:00:14Z
dc.date.issued2021-07
dc.description.abstractIntroduction The purpose of this study was to clarify the role of inflammatory blood markers in the management of early-stage (T1-T2) oral squamous cell carcinoma (OSCC) of the tongue in patients with a clinically negative neck. Materials and methods We undertook a retrospective chart review of 102 patients with early-stage OSCC of the tongue, subjected to tumor resection and elective neck dissection. Based on postsurgical histopathological examination results, we divided our cohort into pN+ and pN0 groups. Afterwards, we analyzed the role of pretreatment inflammatory blood markers in predicting occult neck metastasis. We also evaluated neutrophil-lymphocyte ratio (NLR) association with the depth of invasion (DOI) of the primary tumor. Results We found a significant association of NLR (p=0.001) and monocyte-lymphocyte ratio (p=0.011) with neck status on univariate analysis. Multivariate analysis showed that only NLR (p=0.02) was an independent risk factor for occult metastasis among inflammatory blood markers. Receiver Operating Characteristic curve analysis and Younden's Index determined the NLR value of 2.96 as the most adequate cut-off value for neck status prediction. NLR values of pretreatment workup also had a significant association with the DOI of the primary tumor (p=0.018). Conclusion Our study supports the role of pretreatment NLR in predicting occult neck metastasis in early-stage OSCC of the tongue. It also sheds some light over the potential of NLR as a predictor of the primary tumor's DOI.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVentura E, Barros J, Salgado I, et al. Pretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Study. Cureus. 2021;13(7):e16641. doi:10.7759/cureus.16641pt_PT
dc.identifier.doi10.7759/cureus.16641pt_PT
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.16/2895
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCureus, Inc.pt_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/63054-pretreatment-blood-markers-in-the-prediction-of-occult-neck-metastasis-a-10-year-retrospective-study#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectdepth of invasionpt_PT
dc.subjectneutrophil-lymphocyte ratiopt_PT
dc.subjectoccult neck metastasispt_PT
dc.subjectoral cancerpt_PT
dc.subjectsquamous cell carcinomapt_PT
dc.titlePretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPagee16641pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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