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Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendations

2020-08-14Journal article Open access
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dc.contributor.authorFreitas, Egídio
dc.contributor.authorRodrigues, Maria Alexandra
dc.contributor.authorT, Torres
dc.date.accessioned2021-11-16T13:08:06Z
dc.date.available2021-11-16T13:08:06Z
dc.date.issued2020-08-14
dc.description.abstractPalmoplantar pustulosis (PPP) is a rare, chronic, recurrent inflammatory disease that affects the palms and/or the soles with sterile, erupting pustules, which are debilitating and usually resistant to treatment. It has genetic, histopathologic and clinical features that are not present in psoriasis; thus, it can be classified as a variant of psoriasis or as a separate entity. Smoking and upper respiratory infections have been suggested as main triggers of PPP. PPP is a challenging disease to manage, and the treatment approach involves both topical and systemic therapies, as well as phototherapy and targeted molecules. No gold standard therapy has yet been identified, and none of the treatments are curative. In patients with mild disease, control may be achieved with on-demand occlusion of topical agents. In patients with moderate-to-severe PPP, phototherapy or a classical systemic agent (acitretin being the best treatment option, especially in combination with PUVA) may be effective. Refractory patients or those with contraindications to use these therapies may be good candidates for apremilast or biologic therapy, particularly anti-IL-17A and anti-IL-23 agents. Recent PPP trials are focusing on blockage of IL-36 or IL-1 pathways, which play an important role in innate immunity. Indeed, IL-36 isoforms have been strongly implicated in the pathogenesis of psoriasis. Therefore, blockage of the IL-36 pathway has become a new treatment target in PPP, and three studies are currently evaluating the use of monoclonal antibodies that block the IL-36 receptor in PPP: ANB019 and spesolimab (BI 655130). In this review, we explore the diagnosis, screening and treatment of patients with PPP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFreitas E, Rodrigues MA, Torres T. Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendations. Clin Cosmet Investig Dermatol. 2020;13:561-578. doi:10.2147/CCID.S240607pt_PT
dc.identifier.doi10.2147/CCID.S240607pt_PT
dc.identifier.issn1178-7015
dc.identifier.urihttp://hdl.handle.net/10400.16/2556
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/diagnosis-screening-and-treatment-of-patients-with-palmoplantar-pustul-peer-reviewed-fulltext-article-CCIDpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectANB019pt_PT
dc.subjectIL36pt_PT
dc.subjectpalmoplantar pustulosispt_PT
dc.subjectpalmoplantar pustulosis psoriasispt_PT
dc.subjectspesolimabpt_PT
dc.titleDiagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage578pt_PT
oaire.citation.startPage561pt_PT
oaire.citation.titleClinical, Cosmetic and Investigational Dermatologypt_PT
oaire.citation.volume13pt_PT
person.familyNameFreitas
person.familyNameTorres
person.givenNameEgídio
person.givenNameTiago
person.identifier1077508
person.identifier.ciencia-idFF1B-8834-7AE0
person.identifier.orcid0000-0002-0268-7630
person.identifier.orcid0000-0003-0404-0870
person.identifier.ridC-2604-2014
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication252f03ee-b2b2-464b-9ecf-79b7b58105b6
relation.isAuthorOfPublication99c82895-36fa-49af-927a-f75fa1f9bd56
relation.isAuthorOfPublication.latestForDiscovery99c82895-36fa-49af-927a-f75fa1f9bd56

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