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Pericardial and pleural effusions associated with sirolimus and discussion of possible mechanisms

2012Journal article Open access
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dc.contributor.authorRocha, S.
dc.contributor.authorPedroso, S.
dc.contributor.authorAlmeida, M.
dc.contributor.authorDias, L.
dc.contributor.authorMartins, L.
dc.contributor.authorCastro-Henriques, A.
dc.contributor.authorCabrita, A.
dc.date.accessioned2013-12-26T17:59:55Z
dc.date.available2013-12-26T17:59:55Z
dc.date.issued2012
dc.description.abstractSirolimus, a mammalian target of rapamycin inhibitor, is an increasingly used immunosuppressant in solid-organ transplantation. There are an increasing number of reports of unusual oedematous adverse effects associated with this drug, including lymphoedema, ascites and pleural effusions, and a few reports of pericardial effusions. No pathophysiological explanation for these phenomena has been disclosed. We report a 33-year-old sirolimus-treated kidney transplant recipient with chronic pericardial and pleural effusions identified nine years after transplantation. He was initially treated for a presumed tuberculous pericarditis, even though cultures for Mycobacterium tuberculosis were negative. After 12 months of antitubercular therapy, visceral effusions persisted. Pericardial effusion was drained and stabilised. After exclusion of other causes, sirolimus toxicity was considered the most likely cause. Two months after discontinuation of sirolimus, visceraleffusions disappeared. Interaction of mammalian target of rapamycin inhibitors with mediators of lymphangiogenesis may be a common link in oedematous states associated with sirolimus.por
dc.identifier.citationPort J Nephrol Hypert 2012; 26(2): 165-169por
dc.identifier.issn2183-1289
dc.identifier.urihttp://hdl.handle.net/10400.16/1545
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociedade Portuguesa de Nefrologiapor
dc.relation.publisherversionhttp://www.spnefro.pt/RPNH/PDFs/n2_2012/artigo_005.pdfpor
dc.subjectImmunosuppressionpor
dc.subjectkidney transplantationpor
dc.subjectlymphangiogenesispor
dc.subjectmTOR inhibitorspor
dc.subjectrapamycinpor
dc.subjectserositispor
dc.titlePericardial and pleural effusions associated with sirolimus and discussion of possible mechanismspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpor
oaire.citation.endPage169por
oaire.citation.issue2por
oaire.citation.startPage165por
oaire.citation.titlePortuguese Journal of Nephrology Hypertensionpor
oaire.citation.volume26por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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