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International multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocol

2021-03Journal article Open access
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dc.contributor.authorCata, Juan
dc.contributor.authorRamirez, Maria
dc.contributor.authorForget, Patrice
dc.contributor.authorChen, Lee-Lynn
dc.contributor.authorDiaz-Cambronero, Oscar
dc.contributor.authorChen, Wankun
dc.contributor.authorWarner, Matthew A
dc.contributor.authorKnopfelmacher Couchonal, Adriana
dc.contributor.authorPelosi, Paolo
dc.contributor.authorCuellar, Luis
dc.contributor.authorCorrales, German
dc.contributor.authorRomero, Carlos
dc.contributor.authorLobo, Francisco
dc.contributor.authorSaager, Leif
dc.contributor.authorCastro Tapia, Jorge
dc.contributor.authorKiberenge, Roy
dc.contributor.authorFeng, Lei
dc.contributor.authorSerpa Neto, Ary
dc.date.accessioned2023-10-31T13:17:06Z
dc.date.available2023-10-31T13:17:06Z
dc.date.issued2021-03
dc.description.abstractIntroduction: Blood transfusion is still common in patients undergoing major cancer surgery. Blood transfusion can be associated with poor prognosis in patients with cancer. Perioperative Care in the Cancer Patient -1 (ARCA-1) aims to assess in a large cohort of patients the current incidence, pattern of practice and associations between perioperative blood transfusions and 1-year survival in patients undergoing major cancer surgery. Methods and analysis: ARCA-1 is a prospective international multicentre observational study that will include adult patients scheduled to have major cancer surgical procedures with the intention to cure, and an overnight planned hospital admission. The study will be opened for 1 year for enrolment (7 January 2020-7 February 2021). Each centre will enrol patients for 30 days. The primary endpoint of this study is all-cause mortality 1 year after major cancer surgery. Secondary endpoints are rate of perioperative blood product use, cancer-specific mortality at 1 year and PFSs and 30-day morbidity and mortality. Ethics and dissemination: This study was approved by the Institutional Review Board at The University of Texas-MD Anderson Cancer Center. The study results will be published in peer-reviewed journals and disseminated at international conferences. Trial registration number: NCT04491409.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCata J, Ramirez M, Forget P, et al. International multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocol. BMJ Open. 2021;11(3):e043453. doi:10.1136/bmjopen-2020-043453pt_PT
dc.identifier.doi10.1136/bmjopen-2020-043453pt_PT
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10400.16/2875
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://bmjopen.bmj.com/content/11/3/e043453pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectadult oncologypt_PT
dc.subjectblood bank & transfusion medicinept_PT
dc.subjectsurgerypt_PT
dc.titleInternational multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPagee043453pt_PT
oaire.citation.titleBMJ Openpt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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