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Post-mortem assessment in vascular dementia: advances and aspirations

2016-08-26Journal article Open access
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dc.contributor.authorMcAleese, K.
dc.contributor.authorAlafuzoff, I.
dc.contributor.authorCharidimou, A.
dc.contributor.authorDe Reuck, J.
dc.contributor.authorGrinberg, L.
dc.contributor.authorHainsworth, A.
dc.contributor.authorHortobagyi, T.
dc.contributor.authorInce, P.
dc.contributor.authorJellinger, K.
dc.contributor.authorGao, J.
dc.contributor.authorKalaria, R.
dc.contributor.authorKovacs, G.
dc.contributor.authorKövari, E.
dc.contributor.authorLove, S.
dc.contributor.authorPopovic, M.
dc.contributor.authorSkrobot, O.
dc.contributor.authorTaipa, R.
dc.contributor.authorThal, D.
dc.contributor.authorWerring, D.
dc.contributor.authorWharton, S.
dc.contributor.authorAttems, J.
dc.date.accessioned2017-05-11T11:51:15Z
dc.date.available2017-05-11T11:51:15Z
dc.date.issued2016-08-26
dc.description.abstractBackground Cerebrovascular lesions are a frequent finding in the elderly population. However, the impact of these lesions on cognitive performance, the prevalence of vascular dementia, and the pathophysiology behind characteristic in vivo imaging findings are subject to controversy. Moreover, there are no standardised criteria for the neuropathological assessment of cerebrovascular disease or its related lesions in human post-mortem brains, and conventional histological techniques may indeed be insufficient to fully reflect the consequences of cerebrovascular disease. Discussion Here, we review and discuss both the neuropathological and in vivo imaging characteristics of cerebrovascular disease, prevalence rates of vascular dementia, and clinico-pathological correlations. We also discuss the frequent comorbidity of cerebrovascular pathology and Alzheimer’s disease pathology, as well as the difficult and controversial issue of clinically differentiating between Alzheimer’s disease, vascular dementia and mixed Alzheimer’s disease/vascular dementia. Finally, we consider additional novel approaches to complement and enhance current post-mortem assessment of cerebral human tissue. Conclusion Elucidation of the pathophysiology of cerebrovascular disease, clarification of characteristic findings of in vivo imaging and knowledge about the impact of combined pathologies are needed to improve the diagnostic accuracy of clinical diagnoses.pt_PT
dc.description.sponsorshipKEM is currently supported by the by the Alzheimer’s Society, UK. LTG was funded by institutional NIH grants (P50AG023501, P01AG019724 and R01 AG040311). TH has received support from the Hungarian Brain Research Program (KTIA_13_NAP-A-II/7). Cerebral tissue for some studies in this consensus was provided by the Newcastle Brain Tissue Resource, which is funded in part by a grant from the UK Medical Research Council (grant number G0400074) and by Brains for Dementia research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Med. 2016 Aug 26;14(1):129pt_PT
dc.identifier.doi10.1186/s12916-016-0676-5pt_PT
dc.identifier.issn1741-7015
dc.identifier.urihttp://hdl.handle.net/10400.16/2086
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttps://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0676-5pt_PT
dc.subjectVascular dementiapt_PT
dc.subjectVascular cognitive impairmentpt_PT
dc.subjectCerebrovascular diseasept_PT
dc.subjectCerebrovascular lesionspt_PT
dc.subjectNeuropathologypt_PT
dc.subjectMagnetic resonance imagingpt_PT
dc.subjectPost-mortem MRIpt_PT
dc.subjectMixed dementiapt_PT
dc.titlePost-mortem assessment in vascular dementia: advances and aspirationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage129pt_PT
oaire.citation.titleBMC Medicinept_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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