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Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study

2019Journal article Open access
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dc.contributor.authorFerrari, Fiorenza
dc.contributor.authorRomero-González, Gregorio
dc.contributor.authorTopete, Lilia Rizo
dc.contributor.authorSenzolo, Mara
dc.contributor.authorLorenzin, Anna
dc.contributor.authorHusain-Syed, Faeq
dc.contributor.authorPuci, Mariangela Valentina
dc.contributor.authorFerraro, Ottavia Eleonora
dc.contributor.authorMuraro, Eva
dc.contributor.authorSerrano-Soto, Mara
dc.contributor.authorTriviño, Alejandra Molano
dc.contributor.authorCastro, Ana
dc.contributor.authorXie, Yun
dc.contributor.authorYang, Bo
dc.contributor.authorDe Cal, Massimo
dc.contributor.authorCorradi, Valentina
dc.contributor.authorBrendolan, Alessandra
dc.contributor.authorScarpa, Marta
dc.contributor.authorCarta, Maria Rosa
dc.contributor.authorGiavarina, Davide
dc.contributor.authorBonato, Raffaele
dc.contributor.authorRonco, Claudio
dc.date.accessioned2020-08-24T11:42:05Z
dc.date.available2020-08-24T11:42:05Z
dc.date.issued2019
dc.description.abstractThe urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2]∙[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2]∙[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2]∙[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2]∙[IGFBP7] ≤0.3 and >0.3 (ng/ml)2/1000 (31.9% and 68.10% respectively; p < 0.001). Patients with AKI had higher biomarker values compared to those without AKI (0.66 (0.21-2.84) vs 0.22 (0.08-0.63) (ng/ml)2/1000; p < 0.001). [TIMP-2]∙[IGFBP7] at ICU admission had a lower performance in predicting AKI at any stage within 48 hours and 7 days after measurement (area under the receiver operating characteristic curve (AUC) equal to 0.70 (95%CI 0.65-0.76), AUC 0.68 (95%CI 0.63-0.73)). In the logistic regression model, 0.1 (ng/ml)2/1000-unit increment was likely to increase the risk of AKI by 2% (p = 0.002).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerrari F, Romero-González G, Topete LR, et al. Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study. Sci Rep. 2019;9(1):16484. Published 2019 Nov 11. doi:10.1038/s41598-019-52790-6pt_PT
dc.identifier.doi10.1038/s41598-019-52790-6pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.16/2446
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-52790-6pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleRoutine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage16484pt_PT
oaire.citation.titleScientific reportspt_PT
oaire.citation.volume9pt_PT
person.familyNameFerrari
person.familyNameCastro
person.givenNameFiorenza
person.givenNameAna
person.identifier.ciencia-idC012-7D92-E4A3
person.identifier.orcid0000-0001-6001-7072
person.identifier.orcid0000-0001-8328-2805
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7bee45a7-5ba0-432e-9ea2-39ddb9bbcc57
relation.isAuthorOfPublication84cd7cbf-1683-4893-a73a-da16a8a4cdd3
relation.isAuthorOfPublication.latestForDiscovery7bee45a7-5ba0-432e-9ea2-39ddb9bbcc57

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