Six-Year Complete Remission of Type-1 Diabetes Mellitus in an Adult Treated With Sitagliptin

Benido Silva, Vânia; Pereira, Maria Teresa

Publication

Six-Year Complete Remission of Type-1 Diabetes Mellitus in an Adult Treated With Sitagliptin

2023-01Journal article

dc.contributor.author	Benido Silva, Vânia
dc.contributor.author	Pereira, Maria Teresa
dc.date.accessioned	2024-06-17T14:38:54Z
dc.date.available	2024-06-17T14:38:54Z
dc.date.issued	2023-01
dc.description.abstract	A "honeymoon" phase is a transient period of type 1 diabetes (T1D) remission, characterized by a significant reduction in insulin requirements and good glycemic control due to a temporary restoration of pancreatic β-cell function. This phenomenon occurs in about 60% of adults with this disease, is usually partial, and lasts for up to 1 year. We present a case of a 6-year complete remission of T1D in a 33-year-old man, the longest remission ever described in the literature to our knowledge. He was referred for presenting a 6-month history of polydipsia, polyuria, and weight loss of 5 kg. Laboratory studies confirmed the diagnosis of T1D (fasting blood glucose of 270 mg/dL; HbA1c of 10.6%, and positive antiglutamic acid decarboxylase), and the patient started intensive insulin therapy. After 3 months, a complete remission of the disease was assumed, he suspended insulin administration and since then, he has been under treatment with sitagliptin 100 mg daily, a low-carbohydrate diet, and regular aerobic physical activity. This work aims to highlight the potential role of these factors in delaying disease progression and preserving pancreatic β-cells when introduced at the time of presentation. More robust, prospective, and randomized studies will be needed to confirm its protective effect on the natural course of the disease and support its indication in adults with newly diagnosed T1D.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Benido Silva V, Pereira MT. Six-Year Complete Remission of Type-1 Diabetes Mellitus in an Adult Treated With Sitagliptin. Cureus. 2023;15(1):e34376. doi:10.7759/cureus.34376	pt_PT
dc.identifier.doi	10.7759/cureus.34376	pt_PT
dc.identifier.issn	2168-8184
dc.identifier.uri	http://hdl.handle.net/10400.16/2929
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Cureus, Inc.	pt_PT
dc.relation.publisherversion	https://www.cureus.com/articles/135749-six-year-complete-remission-of-type-1-diabetes-mellitus-in-an-adult-treated-with-sitagliptin#!/	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	dipeptidyl peptidase 4 (dpp-4)	pt_PT
dc.subject	honeymoon phase	pt_PT
dc.subject	low-carb	pt_PT
dc.subject	remission	pt_PT
dc.subject	type 1 diabetes	pt_PT
dc.title	Six-Year Complete Remission of Type-1 Diabetes Mellitus in an Adult Treated With Sitagliptin	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.conferencePlace	United States of America	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	e34376	pt_PT
oaire.citation.title	Cureus	pt_PT
oaire.citation.volume	15	pt_PT
person.familyName	Benido Silva
person.familyName	Pereira
person.givenName	Vânia
person.givenName	Maria Teresa
person.identifier.orcid	0000-0002-8206-7414
person.identifier.orcid	0000-0001-8073-9734
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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relation.isAuthorOfPublication	344d788b-4117-41c8-a131-e37691d312ec
relation.isAuthorOfPublication.latestForDiscovery	cbbb5c72-022e-4e03-a15c-0308feab5acb