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Female preponderance in genetic generalized epilepsies

2021-10Journal article Open access
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dc.contributor.authorVideira, Gonçalo
dc.contributor.authorGabriel, Denis
dc.contributor.authorFreitas, Joel
dc.contributor.authorSamões, Raquel
dc.contributor.authorChorão, Rui
dc.contributor.authorLopes, João
dc.contributor.authorRamalheira, João; Ramalheira, João E.P.
dc.contributor.authorLemos, Carolina
dc.contributor.authorLeal, Bárbara
dc.contributor.authorda Silva, António Martins
dc.contributor.authorChaves, J
dc.date.accessioned2024-01-30T12:47:45Z
dc.date.available2024-01-30T12:47:45Z
dc.date.issued2021-10
dc.description.abstractIntroduction: Epilepsy is more prevalent in men but Genetic Generalized Epilepsies (GGE) seem to be more common in women. A predominant maternal inheritance has been previously described in GGE. Our objective was to determine sex and inheritance patterns in a GGE population compared to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLEHS). Methods: We performed a prospective observational study including adult GGE and MTLEHS patients followed up at a tertiary epilepsy center from January 2016 to December 2019. Patients' familial history was obtained by a detailed questionnaire. Clinical and demographic data was retrieved from clinical notes. Results: A cohort of 641 patients, 403 with GGE and 238 with MTLEHS, was analyzed. GGE was more common in women than MTLEHS (58.8% vs 44.5%, OR=1.63, p = 0.004). Compared to MTLEHS patients, more GGE patients had familial history of epilepsy (45.4% vs 25.2%; p<0.001). The GGE group had a higher percentage of female relatives with epilepsy (55% vs 37%; p = 0.006). The prevalence of maternal inheritance was not different between GGE and MTLEHS groups (62.9% vs 57.7%; p = 0.596). Photosensitivity was more common in females than in males (44.7% vs 34.3%, p = 0.036). Conclusion: There is a female preponderance in GGE when compared to MTLEHS, as both GGE patients and their affected relatives are more frequently women. The prevalence of maternal inheritance was not higher in GGE than in MTLEHS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVideira G, Gabriel D, Freitas J, et al. Female preponderance in genetic generalized epilepsies. Seizure. 2021;91:167-171. doi:10.1016/j.seizure.2021.06.014pt_PT
dc.identifier.doi10.1016/j.seizure.2021.06.014pt_PT
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.urihttp://hdl.handle.net/10400.16/2908
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.seizure-journal.com/article/S1059-1311(21)00199-0/fulltextpt_PT
dc.subjectGenetic generalized epilepsiespt_PT
dc.subjectMaternal inheritancept_PT
dc.subjectPhotosensitivitypt_PT
dc.subjectSexpt_PT
dc.titleFemale preponderance in genetic generalized epilepsiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.endPage171pt_PT
oaire.citation.startPage167pt_PT
oaire.citation.titleSeizurept_PT
oaire.citation.volume91pt_PT
person.familyNameVideira
person.familyNameFernandes de Gabriel
person.familyNameSamões
person.familyNameChorão
person.familyNamede Paiva Ramalheira
person.familyNameChaves
person.givenNameGonçalo
person.givenNameDenis
person.givenNameRaquel
person.givenNameRui
person.givenNameJoão Eduardo
person.givenNameJoão
person.identifier.ciencia-id1F1C-1282-CD8B
person.identifier.ciencia-idC213-964C-1D07
person.identifier.orcid0000-0001-9037-3449
person.identifier.orcid0000-0002-6275-8656
person.identifier.orcid0000-0001-8296-883X
person.identifier.orcid0000-0003-0995-7370
person.identifier.orcid0000-0002-1741-0300
person.identifier.orcid0000-0003-4454-5232
person.identifier.scopus-author-id12446353200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverye32f0c06-7f53-493d-a438-c1e8ab15eeb7

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