Publication
CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review
dc.contributor.author | Guerreiro, M. | |
dc.contributor.author | Príncipe, F. | |
dc.contributor.author | Teles, M. | |
dc.contributor.author | Fonseca, S. | |
dc.contributor.author | Santos, A. | |
dc.contributor.author | Fonseca, E. | |
dc.contributor.author | Gomes, P. | |
dc.contributor.author | Marques, C. | |
dc.contributor.author | Lima, M. | |
dc.date.accessioned | 2018-07-12T12:29:44Z | |
dc.date.available | 2018-07-12T12:29:44Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε+ and surface CD3-, CD2+, and CD56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Case Reports in Hematology, vol. 2017, Article ID 3724017, 9 pages, 2017. https://doi.org/10.1155/2017/3724017 | pt_PT |
dc.identifier.doi | 10.1155/2017/3724017 | pt_PT |
dc.identifier.issn | 2090-6560 | |
dc.identifier.issn | 2090-6579 | |
dc.identifier.uri | http://hdl.handle.net/10400.16/2211 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Hindawi Publishing Corporation | pt_PT |
dc.relation.publisherversion | https://www.hindawi.com/journals/crihem/2017/3724017/ | pt_PT |
dc.title | CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.conferencePlace | United States of America | pt_PT |
oaire.citation.startPage | 3724017 | pt_PT |
oaire.citation.title | Case Reports in Hematology | pt_PT |
oaire.citation.volume | 2017 | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |