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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review

2017Journal article Open access
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dc.contributor.authorGuerreiro, M.
dc.contributor.authorPríncipe, F.
dc.contributor.authorTeles, M.
dc.contributor.authorFonseca, S.
dc.contributor.authorSantos, A.
dc.contributor.authorFonseca, E.
dc.contributor.authorGomes, P.
dc.contributor.authorMarques, C.
dc.contributor.authorLima, M.
dc.date.accessioned2018-07-12T12:29:44Z
dc.date.available2018-07-12T12:29:44Z
dc.date.issued2017
dc.description.abstractAggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε+ and surface CD3-, CD2+, and CD56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCase Reports in Hematology, vol. 2017, Article ID 3724017, 9 pages, 2017. https://doi.org/10.1155/2017/3724017pt_PT
dc.identifier.doi10.1155/2017/3724017pt_PT
dc.identifier.issn2090-6560
dc.identifier.issn2090-6579
dc.identifier.urihttp://hdl.handle.net/10400.16/2211
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/crihem/2017/3724017/pt_PT
dc.titleCD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.startPage3724017pt_PT
oaire.citation.titleCase Reports in Hematologypt_PT
oaire.citation.volume2017pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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