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Peripheral neuropathy in systemic vasculitis and other autoimmune diseases – a report of five cases emphasizing the importance of etiologic characterization

2020-09-11Journal article Open access
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dc.contributor.authorRodrigues, Rita
dc.contributor.authorBranco, Mariana
dc.contributor.authorSilva, Renata
dc.contributor.authorRuano, Luís
dc.contributor.authorFontão, Luís
dc.contributor.authorLopes, Marta
dc.contributor.authorScigliano, Horácio
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorPires, Manuel
dc.contributor.authorSantos, Catarina
dc.date.accessioned2021-11-22T13:25:32Z
dc.date.available2021-11-22T13:25:32Z
dc.date.issued2020-09-11
dc.description.abstractIntroduction: Peripheral neuropathies may present in the context of systemic vasculitis and other autoimmune diseases. The etiologic characterization is crucial to define the treatment and prognosis in secondary vasculitis. The purpose of this study is to describe the pathway of etiologic investigation including the role of nerve biopsy. Methods: Retrospective analysis of patients seen in the neuromuscular outpatient clinic during the last four years with peripheral neuropathy in the context of systemic vasculitis or other autoimmune diseases. Results: We present five patients with stepwise progressive sensorimotor deficits of upper and lower limbs. All patients presented with systemic features and one of them had an established diagnosis of systemic vasculitis. They underwent an extended blood panel, including autoimmune and serologic tests. Electromyography and nerve conduction studies revealed asymmetric axonal sensorimotor polyneuropathies in four patients, and an axonal sensorimotor multiple mononeuropathy in one. Four patients underwent nerve biopsy and the other performed a skin biopsy, with findings suggestive of possible vasculitic processes. The etiologies identified included microscopic polyangiitis, HBV-related polyarteritis nodosa and two eosinophilic granulomatosis with polyangiitis. In the last patient a specific etiology could not be established. Conclusion: This series reveals the etiologic and phenotypic diversity of peripheral neuropathies related with systemic vasculitis. The therapeutic approach and prognosis were distinct in each patient, emphasizing the importance of a prompt diagnosis and appropriate treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues R, Branco M, Silva R, et al. Peripheral neuropathy in systemic vasculitis and other autoimmune diseases - a report of five cases emphasizing the importance of etiologic characterization. eNeurologicalSci. 2020;21:100272. doi:10.1016/j.ensci.2020.100272pt_PT
dc.identifier.doi10.1016/j.ensci.2020.100272pt_PT
dc.identifier.issn2405-6502
dc.identifier.urihttp://hdl.handle.net/10400.16/2590
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2405650220300514?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAcquired polyneuropathypt_PT
dc.subjectMultiple mononeuropathypt_PT
dc.subjectNerve biopsypt_PT
dc.subjectNeuropathologypt_PT
dc.subjectSystemic vasculitispt_PT
dc.titlePeripheral neuropathy in systemic vasculitis and other autoimmune diseases – a report of five cases emphasizing the importance of etiologic characterizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage100272pt_PT
oaire.citation.titleeNeurologicalScipt_PT
oaire.citation.volume21pt_PT
person.familyNameFerreira Taipa
person.familyNamePires
person.givenNameRicardo Jorge
person.givenNameManuel
person.identifier.ciencia-idE316-D53D-8537
person.identifier.orcid0000-0002-9260-0227
person.identifier.orcid0000-0002-0046-6455
person.identifier.scopus-author-id7102122793
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication97a7bf34-226a-4dc2-ae31-d0f86030cb52
relation.isAuthorOfPublication07361da1-f095-4eb3-9856-a76e41bd21a6
relation.isAuthorOfPublication.latestForDiscovery97a7bf34-226a-4dc2-ae31-d0f86030cb52

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