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Malignancy after renal transplantation: a single-centre experience

dc.contributor.authorVieira, P.
dc.contributor.authorBareto, P.
dc.contributor.authorPedroso, S.
dc.contributor.authorAlmeida, M.
dc.contributor.authorMartins, L.
dc.contributor.authorDias, L.
dc.contributor.authorCastro-Henriques, A.
dc.contributor.authorCabrita, A.
dc.date.accessioned2018-10-29T16:31:48Z
dc.date.available2018-10-29T16:31:48Z
dc.date.issued2016
dc.description.abstractIntroduction: Malignancy management in renal transplant recipients is becoming a major factor affecting long‑term patient survival. Thus, we intended to evaluate both incidence and prognosis of malignant diseases following renal transplantation at a single centre in Portugal. Methods: We studied retrospectively the 2,358 patients who underwent kidney transplantation (KT) between 1983 and 2014. Apart from descriptive analysis, both demographic and clinical characteristics of cancer and non‑cancer cancer patients were compared. Results: During a median follow‑up of 118 (IQR 57‑179) months, 139 patients (5.8%) developed 158 de novo malignancies, with a median time from KT to diagnosis of 76..5 (IQR 21.0‑132.0) months. When compared to non‑cancer patients, they were older at KT date, had longer graft survival and a lower living donor recipients’ prevalence. As for post-transplant malignancies analysis, the most common were non‑cutaneous non‑lymphomatous cancers (49.4%, n=78), skin cancers (35.4%, n=56) and post‑transplant lymphoproliferative disorders (9.5%, n=15). Considering specific diagnosis, squamous cell carcinoma and basal cell carcinoma with 17.1% and 16.5% respectively, and non‑Hodgkin lymphomas with 7.6%, were the most frequent. Global mortality among cancer patients was 36.0%, with a median time of 9.7 (IQR 1.9‑17.5) months from time of diagnosis to death. As for survival analysis, cancer patient survival was significantly lower while censored graft survival was significantly higher in this group. Conclusion: Incidence and characteristics of malignancy following renal transplantation in our unit are similar to those globally described, despite some traits probably a result of specific ethnic and environmental characteristics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPort J Nephrol Hypert 2016; 30(3): 205-209pt_PT
dc.identifier.issn2183-1289
dc.identifier.urihttp://hdl.handle.net/10400.16/2243
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Nefrologiapt_PT
dc.relation.publisherversionhttp://www.spnefro.pt/rpnh/browse_all_issues/61_volume_30_number_3pt_PT
dc.subjectepidemiologypt_PT
dc.subjectkidney transplantationpt_PT
dc.subjectneoplasmspt_PT
dc.titleMalignancy after renal transplantation: a single-centre experiencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpt_PT
oaire.citation.endPage209pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage205pt_PT
oaire.citation.titlePortuguese Journal of Nephrology and Hypertensionpt_PT
oaire.citation.volume30pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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