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Burden of Community-Acquired Pneumonia and Unmet Clinical Needs

2020Journal article Open access
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dc.contributor.authorFerreira-Coimbra, João
dc.contributor.authorSarda, Cristina
dc.contributor.authorRello, Jordi
dc.date.accessioned2021-06-21T14:39:48Z
dc.date.available2021-06-21T14:39:48Z
dc.date.issued2020
dc.description.abstractCommunity-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Despite important advances in prevention through vaccines, new rapid diagnostic tests and antibiotics, CAP management still has significant drawbacks. Mortality remains very high in severely ill patients presenting with respiratory failure or shock but is also high in the elderly. Even after a CAP episode, higher risk of death remains during a long period, a risk mainly driven by inflammation and patient-related co-morbidities. CAP microbiology has been altered by new molecular diagnostic tests that have turned viruses into the most identified pathogens, notwithstanding uncertainties about the specific role of each virus in CAP pathogenesis. Pneumococcal vaccines also impacted CAP etiology and thus had changed Streptococcus pneumoniae circulating serotypes. Pathogens from specific regions should also be kept in mind when treating CAP. New antibiotics for CAP treatment were not tested in severely ill patients and focused on multidrug-resistant pathogens that are unrelated to CAP, limiting their general use and indications for intensive care unit (ICU) patients. Similarly, CAP management could be personalized through the use of adjunctive therapies that showed outcome improvements in particular patient groups. Although pneumococcal vaccination was only convincingly shown to reduce invasive pneumococcal disease, with a less significant effect in pneumococcal CAP, it remains the best therapeutic intervention to prevent bacterial CAP. Further research in CAP is needed to reduce its population impact and improve individual outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira-Coimbra J, Sarda C, Rello J. Burden of Community-Acquired Pneumonia and Unmet Clinical Needs. Adv Ther. 2020 Apr;37(4):1302-1318. doi: 10.1007/s12325-020-01248-7. Epub 2020 Feb 18. PMID: 32072494pt_PT
dc.identifier.doi10.1007/s12325-020-01248-7pt_PT
dc.identifier.issn1865-8652
dc.identifier.urihttp://hdl.handle.net/10400.16/2477
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Healthcare Communicationspt_PT
dc.relation.publisherversionhttps://link.springer.com/content/pdf/10.1007/s12325-020-01248-7.pdfpt_PT
dc.subjectCAPpt_PT
dc.subjectCommunity-acquired pneumoniapt_PT
dc.subjectEpidemiologypt_PT
dc.subjectInfectious diseasept_PT
dc.titleBurden of Community-Acquired Pneumonia and Unmet Clinical Needspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage1318pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1302pt_PT
oaire.citation.titleAdvances in therapypt_PT
oaire.citation.volume37pt_PT
person.familyNameFerreira Coimbra
person.givenNameJoão
person.identifier.orcid0000-0002-5855-8600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc1c9f3b-f81e-4494-a4f1-bbeb560463ba
relation.isAuthorOfPublication.latestForDiscoverycc1c9f3b-f81e-4494-a4f1-bbeb560463ba

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