Repository logo
 
Publication

Discordance between patient and physician global assessment of disease activity in Behçet's syndrome: a multicenter study cohort

2020Journal article Open access
Simple item page
dc.contributor.authorFloris, Alberto
dc.contributor.authorEspinosa, Gerard
dc.contributor.authorSerpa Pinto, Luísa
dc.contributor.authorKougkas, Nikolaos
dc.contributor.authorLo Monaco, Andrea
dc.contributor.authorLopalco, Giuseppe
dc.contributor.authorOrlando, Ida
dc.contributor.authorBertsias, George
dc.contributor.authorCantarini, Luca
dc.contributor.authorCervera, Ricard
dc.contributor.authorAraújo Correia, João
dc.contributor.authorGovoni, Marcello
dc.contributor.authorIannone, Florenzo
dc.contributor.authorMathieu, Alessandro
dc.contributor.authorNeri, Piergiorgio
dc.contributor.authorMartins da Silva, Ana
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorMuntoni, Monica
dc.contributor.authorCauli, Alberto
dc.contributor.authorPiga, Matteo
dc.date.accessioned2021-07-06T17:21:09Z
dc.date.available2021-07-06T17:21:09Z
dc.date.issued2020
dc.description.abstractBackground: To compare the patients' and physician's global assessment of disease activity in Behçet's syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance. Methods: A total of 226 adult BS patients with a median (IQR) age of 46.9 (35.6-55.2) years were enrolled across Italy, Greece, Portugal, and Spain. Demographic, clinical, and therapeutic variables, as well as the patient reported outcomes, were collected at the recruitment visit. The physical (PCS) and mental (MCS) component summary scores of the Short Form Questionnaire 36 (SF-36) and the Behçet's syndrome Overall Damage Index (BODI) were calculated. Disease activity was assessed by the patients' (PtGA) and physician's global assessment (PGA) in a 10-cm visual analog scale, as well as the Behçet Disease Current Activity Form (BDCAF). Discordance (∆) was calculated by subtracting the PGA from the PtGA and defined as positive (PtGA>PGA) and negative (PtGA<PGA) discordance using both a more stringent (∆ = ±2) and a less stringent (∆ = ±1) cutoff. Univariate and multivariate logistic regressions were performed. Results: Median PtGA and PGA scores were 2.0 (0.3-5.0) and 1.0 (0.0-3.0) cm, respectively. The discordance prevalence varied (from 29.6 to 55.3%) according to the cutoff applied, and the majority (> 80%) of disagreements were due to patients rating higher their disease activity. Higher values of BDCAF were associated to increased rate of positive discordance. When BDCAF = 0, the median (IQR) values of PtGA and PGA were 0.2 (0-2) and 0 (0-1), respectively. PCS (adjusted odds ratio (adjOR) 0.96 per unit, 95% CI 0.93-0.98, p = 0.006) and MCS (adjOR 0.96 per unit, 95% CI 0.93-0.99, p = 0.003) were independently associated with positive discordance using both cutoffs. Active ocular involvement emerged as a potential determinant of negative discordance (adjOR 5.88, 95% CI 1.48-23.30, p = 0.012). Conclusions: PtGA and PGA should be considered as complementary measures in BS, as patients and physicians may be influenced by different factors when assessing active disease manifestations. Particularly, PtGA may be a useful tool in the assessment of BS disease activity, as it carries a low risk to misclassify an inactive disease, and may allow to capture aspects of the patient's health that negatively affect his well-being and the treatment.pt_PT
dc.description.sponsorshipThe BODI Project was partly supported by a grant from the Italian Behçet’s Syndrome Patient Association (SIMBA ONLUS).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFloris A, Espinosa G, Serpa Pinto L, Kougkas N, Lo Monaco A, Lopalco G, Orlando I, Bertsias G, Cantarini L, Cervera R, Correia J, Govoni M, Iannone F, Mathieu A, Neri P, Martins Silva A, Vasconcelos C, Muntoni M, Cauli A, Piga M; BODI Project collaborators. Discordance between patient and physician global assessment of disease activity in Behçet's syndrome: a multicenter study cohort. Arthritis Res Ther. 2020 Nov 25;22(1):278. doi: 10.1186/s13075-020-02362-1. PMID: 33239083; PMCID: PMC7687797.pt_PT
dc.identifier.doi10.1186/s13075-020-02362-1pt_PT
dc.identifier.issn1478-6362
dc.identifier.urihttp://hdl.handle.net/10400.16/2486
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttps://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02362-1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBehçet’s syndromept_PT
dc.subjectDisease activitypt_PT
dc.subjectOutcome measurept_PT
dc.subjectPatients reported outcomespt_PT
dc.titleDiscordance between patient and physician global assessment of disease activity in Behçet's syndrome: a multicenter study cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage278pt_PT
oaire.citation.titleArthritis research & therapypt_PT
oaire.citation.volume22pt_PT
person.familyNameSerpa Pinto
person.familyNameAraújo Correia
person.familyNameMartins da Silva
person.givenNameLuísa
person.givenNameJoão
person.givenNameAna
person.identifier.ciencia-id1116-6606-5CF5
person.identifier.orcid0000-0001-5115-4905
person.identifier.orcid0000-0002-6742-3900
person.identifier.orcid0000-0002-1409-0831
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9653846d-d3c7-4760-b306-0723c927ab22
relation.isAuthorOfPublication311498cd-e659-41ad-b466-6ea2d864ebe4
relation.isAuthorOfPublicatione2fd5aa2-f733-43eb-b339-14fcaa3d881d
relation.isAuthorOfPublication.latestForDiscoverye2fd5aa2-f733-43eb-b339-14fcaa3d881d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Floris-2020-Discordance-between-patient-and-phy.pdf
Size:
965.62 KB
Format:
Adobe Portable Document Format
Download

Collections

UIC - Artigos publicados em revistas indexadas na Medline
SN - Artigos publicados em revistas indexadas na Pubmed/Medline