Treatable Traits in COPD – A Proposed Approach

Cardoso, João; Ferreira, António Jorge; Guimarães, Miguel; Oliveira, Ana Sofia; Simão, Paula; Sucena, Maria

Publication

Treatable Traits in COPD – A Proposed Approach

2021-11Journal article

dc.contributor.author	Cardoso, João
dc.contributor.author	Ferreira, António Jorge
dc.contributor.author	Guimarães, Miguel
dc.contributor.author	Oliveira, Ana Sofia
dc.contributor.author	Simão, Paula
dc.contributor.author	Sucena, Maria
dc.date.accessioned	2023-10-31T11:38:52Z
dc.date.available	2023-10-31T11:38:52Z
dc.date.issued	2021-11
dc.description.abstract	The well-recognized individual heterogeneity within COPD patients has led to a growing interest in greater personalization in the approach of these patients. Thus, the treatable traits strategy has been proposed as a further step towards precision medicine in the management of chronic airway disease, both in stable phase and acute exacerbations. The aim of this paper is to perform a critical review on the treatable traits strategy and propose a guide to approach COPD patients in the light of this new concept. An innovative stepwise approach is proposed - a multidisciplinary model based on two distinct phases, with the potential to be implemented in both primary care and hospital settings. The first phase is the initial and focused assessment of a selected subset of treatable traits, which should be addressed in all COPD patients in both settings (primary care and hospital). As some patients may present with advanced disease at diagnosis or may progress despite this initial treatment requiring a more specialized assessment, they should progress to a second phase, in which a broader approach is recommended. Beyond stable COPD, we explore how the treatable traits strategy may be applied to reduce the risk of future exacerbations and improve the management of COPD exacerbations. Since many treatable traits have already been related to exacerbation risk, the strategy proposed here represents an opportunity to be proactive. Although it still lacks prospective validation, we believe this is the way forward for the future of the COPD approach.	pt_PT
dc.description.sponsorship	This article was funded by Bial. Bial provided all necessary scientific bibliography and funded medical writing support and publishing charges. The authors did not receive direct funding for the writing of this article	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Cardoso J, Ferreira AJ, Guimarães M, Oliveira AS, Simão P, Sucena M. Treatable Traits in COPD - A Proposed Approach. Int J Chron Obstruct Pulmon Dis. 2021;16:3167-3182. doi:10.2147/COPD.S330817	pt_PT
dc.identifier.doi	10.2147/COPD.S330817	pt_PT
dc.identifier.issn	1176-9106
dc.identifier.issn	1178-2005
dc.identifier.uri	http://hdl.handle.net/10400.16/2866
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Dove Medical Press	pt_PT
dc.relation.publisherversion	https://www.dovepress.com/treatable-traits-in-copd--a-proposed-approach-peer-reviewed-fulltext-article-COPD	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	COPD	pt_PT
dc.subject	future	pt_PT
dc.subject	phased approach	pt_PT
dc.subject	precision medicine	pt_PT
dc.subject	treatable traits strategy	pt_PT
dc.title	Treatable Traits in COPD – A Proposed Approach	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.conferencePlace	New Zealand	pt_PT
oaire.citation.endPage	3182	pt_PT
oaire.citation.startPage	3167	pt_PT
oaire.citation.title	International Journal of Chronic Obstructive Pulmonary Disease	pt_PT
oaire.citation.volume	Volume 16	pt_PT
person.familyName	Campos Miranda Duarte Sucena
person.givenName	Maria
person.identifier.ciencia-id	5216-37E8-6966
person.identifier.orcid	0000-0002-0115-7080
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isAuthorOfPublication	4968b345-427f-4b1c-8eae-60d6e3d77fe2
relation.isAuthorOfPublication.latestForDiscovery	4968b345-427f-4b1c-8eae-60d6e3d77fe2