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Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum

2021-06Journal article Open access
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dc.contributor.authordas Neves, Sofia Pereira
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorMarques, Fernanda
dc.contributor.authorSoares Costa, Patrício
dc.contributor.authorMonárrez-Espino, Joel
dc.contributor.authorPalha, Joana A.
dc.contributor.authorKivipelto, Miia
dc.date.accessioned2023-12-21T11:57:54Z
dc.date.available2023-12-21T11:57:54Z
dc.date.issued2021-06
dc.description.abstractA worldwide increase in longevity is bringing novel challenges to public health and health care professionals. Cognitive impairment in the elderly may compromise living conditions and precede Alzheimer's disease (AD), the most prevalent form of dementia. Therefore, finding molecular markers associated with cognitive impairment is of crucial importance. Lipocalin 2 (LCN2), an iron-related protein, has been suggested as a potential marker for mild cognitive impairment (MCI) and AD. This study aimed at investigating the association between LCN2 measured in serum and cerebrospinal fluid (CSF) with cognitive impairment. A cross-sectional design based on two aging cohorts was used: individuals diagnosed with subjective cognitive complaints (SCC), MCI, and AD from a Swedish memory clinic-based cohort, and individuals diagnosed with SCC and AD from a Portuguese cohort. Binary logistic [for the outcome cognitive impairment (MCI + AD) in the Swedish cohort and AD in the Portuguese cohort] and multinomial logistic (for the outcomes MCI and AD) regression analyses were used. No associations were found in both cohorts when controlling for sex, education, and age. This explanatory study suggests that the association between serum and CSF LCN2 concentrations with cognitive impairment reported in the literature must be further analyzed for confounders.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationdas Neves SP, Taipa R, Marques F, et al. Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum. Front Aging Neurosci. 2021;13:663837.doi:10.3389/fnagi.2021.663837pt_PT
dc.identifier.doi10.3389/fnagi.2021.663837pt_PT
dc.identifier.issn1663-4365
dc.identifier.urihttp://hdl.handle.net/10400.16/2901
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Research Foundationpt_PT
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relationExplorar o papel dos atrócitos na patofisiologia da Esclerose Múltipla
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.663837/fullpt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectbiomarkerpt_PT
dc.subjectcognitionpt_PT
dc.subjectlipocalin 2pt_PT
dc.subjectmild-cognitive impairmentpt_PT
dc.titleAssociation Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLA - ICVS/3B's - Associate Laboratory
oaire.awardTitleExplorar o papel dos atrócitos na patofisiologia da Esclerose Múltipla
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F114120%2F2015/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.startPage663837pt_PT
oaire.citation.titleFrontiers in Aging Neurosciencept_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira Taipa
person.givenNameRicardo Jorge
person.identifier.ciencia-idE316-D53D-8537
person.identifier.orcid0000-0002-9260-0227
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication97a7bf34-226a-4dc2-ae31-d0f86030cb52
relation.isAuthorOfPublication.latestForDiscovery97a7bf34-226a-4dc2-ae31-d0f86030cb52
relation.isProjectOfPublicationc47f1edd-b78a-416e-9e83-254fa6ba610f
relation.isProjectOfPublication401f3560-a3c3-4d4e-ac28-06db978d4f02
relation.isProjectOfPublication.latestForDiscoveryc47f1edd-b78a-416e-9e83-254fa6ba610f

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