Repository logo
 
Publication

Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients

2019Journal article Open access
Simple item page
dc.contributor.authorLascasas, Josefina
dc.contributor.authorFonseca, Isabel
dc.contributor.authorJ, Malheiro
dc.contributor.authorSantos, Sofia
dc.contributor.authorCampos, Andreia
dc.contributor.authorCastro, Ana
dc.contributor.authorMoreira, Carla
dc.contributor.authorCorreia, Sofia
dc.contributor.authorBeirão, Idalina
dc.contributor.authorLobato, Luísa
dc.contributor.authorCabrita, Antonio
dc.date.accessioned2021-08-20T19:14:14Z
dc.date.available2021-08-20T19:14:14Z
dc.date.issued2019
dc.description.abstractIntroduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elderly CKD patients, we describe their baseline characteristics, risk profile, and cardiovascular disease burden. Methods: All CKD patients aged 65 years and older referred to our department during 2012 were enrolled. Baseline data included: demographic, CKD stage, medication, comorbid conditions. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI formula. Results: A total of 416 patients, 50% referred by primary care physicians, aged 77 ± 7 years, 52% male, with a median eGFR of 32 mL/min/1.73m2 participated in the study. Fifty percent had diabetes (DM), 85% dyslipidemia, 96% hypertension; 26% were current/former smokers, and 24% had a body mass index > 30 kg/m2. The prevalence of CVD was 62% and higher in stage 4-5 patients; in diabetics, it gradually increased with CKD progression (stage 3a < stage 3b < stage 4-5) (39, 58, 82%; p < 0.001). Conclusions: At baseline, our CKD elderly cohort had a higher burden of CVD. The prevalence of CVD was greater than in other European CKD cohorts. Lower level of eGFR was associated with a greater burden of CVD and was more pronounced in diabetics, highlighting the importance of strategically targeting cardiovascular risk reduction in these patients.pt_PT
dc.description.abstractIntrodução: Doença renal crônica (DRC) é fator de risco independente para vários desfechos desfavoráveis, incluindo doença cardiovascular (DCV), particularmente em idosos, o segmento de crescimento mais rápido da população com doença renal terminal (DRT). Portugal tem a maior incidência europeia não-ajustada e a maior prevalência de DRT. Neste artigo caracterizamos uma coorte de idosos com DRC, referenciados para a nefrologia, com particular ênfase para o risco e carga de doença cardiovascular. Métodos: Foram incluídos todos os pacientes com DRC com 65 anos ou mais encaminhados ao nosso departamento em 2012. Os dados basais incluíram: demografia, estágio da DRC, medicação e comorbidades. A taxa de filtração glomerular (TFGe) foi calculada pela fórmula CKD-EPI. Resultados: Metade dos 416 pacientes incluídos foram encaminhados por médicos da atenção primária; sua idade era 77 ± 7 anos; 52% eram homens; a TFGe mediana era de 32 mL /min/1,73 m2. Metade tinha diabetes (DM), 85% dislipidemia, 96% hipertensão; 26% eram fumantes atuais/ antigos; 24% tinham índice de massa corporal > 30 kg/m2. A prevalência de DCV foi de 62%, sendo maior entre pacientes nos estágios 4-5; em diabéticos, aumentou gradualmente com a progressão da DRC (estágio 3a < estágio 3b < estágio 4-5) (39%, 58%, 82%; p < 0,001). Conclusões: A coorte de idosos com DRC apresentava inicialmente maior carga de DCV. A prevalência de DCV foi maior que em outras coortes europeias com DRC. Níveis menores de TFGe foram associados a carga maior de DCV e foram mais pronunciados entre diabéticos, destacando a importância de objetivar estrategicamente a redução do risco cardiovascular nesses pacientes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLascasas JMSS, Fonseca I, Malheiro J, Santos S, Campos A, Castro A, Moreira C, Correia S, Beirão I, Lobato L, Cabrita A. Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients. J Bras Nefrol. 2019 Jan-Mar;41(1):29-37. doi: 10.1590/2175-8239-JBN-2018-0120. Epub 2019 Jan 10. PMID: 31063177; PMCID: PMC6534027.pt_PT
dc.identifier.doi10.1590/2175-8239-jbn-2018-0120pt_PT
dc.identifier.issn0101-2800
dc.identifier.urihttp://hdl.handle.net/10400.16/2495
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Brasileira de Nefrologiapt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534027/pdf/2175-8239-jbn-2018-0120.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRenal Insufficiency Chronicpt_PT
dc.subjectCardiovascular Diseasespt_PT
dc.subjectAgedpt_PT
dc.subjectInsuficiência Renal Crónicapt_PT
dc.subjectDoenças Cardiovascularespt_PT
dc.subjectIdosopt_PT
dc.titleDemographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patientspt_PT
dc.title.alternativeDados demográficos, características clínicas e peso da doença cardiovascular em uma coorte portuguesa de pacientes idosos com doença renal crónicapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBrazilpt_PT
oaire.citation.endPage37pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage29pt_PT
oaire.citation.titleBrazilian Journal of Nephrologypt_PT
oaire.citation.volume41pt_PT
person.familyNameSousa Santos Lascasas
person.familyNameFonseca
person.familyNameMalheiro
person.familyNameCampos
person.familyNameCastro
person.familyNameCorreia Lopes Lobato
person.familyNameCabrita
person.givenNameJosefina Maria
person.givenNameIsabel
person.givenNameJorge
person.givenNameAndreia
person.givenNameAna
person.givenNameLuísa Maria
person.givenNameAntonio
person.identifier415128
person.identifier.ciencia-idD218-B3AB-719D
person.identifier.ciencia-id6716-A5D1-FB3F
person.identifier.ciencia-idC012-7D92-E4A3
person.identifier.ciencia-idB61E-6079-8F82
person.identifier.orcid0000-0003-0383-4994
person.identifier.orcid0000-0001-8984-1751
person.identifier.orcid0000-0002-9625-5889
person.identifier.orcid0000-0003-0062-5732
person.identifier.orcid0000-0001-8328-2805
person.identifier.orcid0000-0002-1464-083X
person.identifier.orcid0000-0003-3794-9239
person.identifier.ridK-6339-2013
person.identifier.ridK-6320-2013
person.identifier.scopus-author-id55941495000
person.identifier.scopus-author-id26434404600
person.identifier.scopus-author-id57211840457
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication98f055b6-738c-41c4-83c1-ffcfe6d6b33b
relation.isAuthorOfPublication2c7a2607-6376-486e-9ad5-490d0032946c
relation.isAuthorOfPublicationbf3e5709-4eaa-49d7-bbd9-20e9cfe84979
relation.isAuthorOfPublication265cbb13-b6f7-4030-b6fe-eb9b40306f8b
relation.isAuthorOfPublication84cd7cbf-1683-4893-a73a-da16a8a4cdd3
relation.isAuthorOfPublication6ccdc530-edc9-4488-9501-ffd1557573e3
relation.isAuthorOfPublicatione6585113-b703-4899-ab35-2dfd11593588
relation.isAuthorOfPublication.latestForDiscovery2c7a2607-6376-486e-9ad5-490d0032946c

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lascasas2019.pdf
Size:
294.61 KB
Format:
Adobe Portable Document Format
Download

Collections

SNEF - Artigos publicados em revistas indexadas na Pubmed/Medline