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Echocardiographic Assessment of Right Ventriculo-arterial Coupling: Clinical Correlates and Prognostic Impact in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy

2020Journal article Open access
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dc.contributor.authorBragança, Bruno
dc.contributor.authorTrêpa, Maria
dc.contributor.authorBaggen Santos, Raquel
dc.contributor.authorSilveira, Inês
dc.contributor.authorFontes-Oliveira, Marta
dc.contributor.authorSousa, Maria João
dc.contributor.authorHipólito-Reis, António
dc.contributor.authorTorres, Severo
dc.contributor.authorSantos, Mario
dc.date.accessioned2022-01-11T16:23:05Z
dc.date.available2022-01-11T16:23:05Z
dc.date.issued2020
dc.description.abstractBackground: Right ventriculo-arterial coupling (RV-PA) can be estimated by echocardiography using the ratio between tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) and it has prognostic value in the general heart failure (HF) population. We aimed to study the clinical correlates and prognostic value of RV-PA in HF patients undergoing cardiac resynchronization therapy (CRT). Methods: We retrospectively studied 70 HF patients undergoing CRT implantation. Results: RV-PA coupling was estimated by TAPSE/PASP ratio using baseline echocardiography. Non-response to CRT was defined as improvement of left ventricular ejection fraction < 5% in a follow-up echo 6-12 months after CRT. Those with lower TAPSE/PASP ratios (worse RV-PA coupling) had higher NT-proBNP concentrations and increased E/e' ratio. TAPSE/PASP ratio and PASP, but not TAPSE, predicted nonresponse to CRT with TAPSE/PASP ratio showing the best discriminative ability with a sensitivity of 76% and specificity of 71%. Among these parameters, PASP independently predicted all-cause mortality. Conclusions: RV-PA coupling estimated by TAPSE/PASP ratio was associated with established prognostic markers in HF. It numerically outperformed PASP and TAPSE in predicting the response to CRT. Our data suggest that this simple and widely available echocardiographic parameter conveys significant pathophysiological and prognostic meaning in HF patients undergoing CRT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBragança B, Trêpa M, Santos R, et al. Echocardiographic Assessment of Right Ventriculo-arterial Coupling: Clinical Correlates and Prognostic Impact in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy. J Cardiovasc Imaging. 2020;28(2):109-120. doi:10.4250/jcvi.2019.0094pt_PT
dc.identifier.doi10.4250/jcvi.2019.0094pt_PT
dc.identifier.issn2586-7296
dc.identifier.issn2586-7210
dc.identifier.urihttp://hdl.handle.net/10400.16/2657
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKorean Society of Echocardiographypt_PT
dc.relation.publisherversionhttps://e-jcvi.org/DOIx.php?id=10.4250/jcvi.2019.0094pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCardiac resynchronization therapypt_PT
dc.subjectHeart failurept_PT
dc.subjectPulmonary circulationpt_PT
dc.subjectRight ventricle functionpt_PT
dc.subjectRight ventriculo-arterial couplingpt_PT
dc.titleEchocardiographic Assessment of Right Ventriculo-arterial Coupling: Clinical Correlates and Prognostic Impact in Heart Failure Patients Undergoing Cardiac Resynchronization Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceKorea (South)pt_PT
oaire.citation.endPage120pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage109pt_PT
oaire.citation.titleJournal of Cardiovascular Imagingpt_PT
oaire.citation.volume28pt_PT
person.familyNameBragança
person.familyNameTrêpa
person.familyNameBaggen Santos
person.familyNameSilveira
person.familyNameFontes-Oliveira
person.familyNameSousa
person.familyNameHipólito Reis
person.familyNameTorres
person.familyNameSantos
person.givenNameBruno
person.givenNameMaria
person.givenNameRaquel
person.givenNameInês
person.givenNameMarta
person.givenNameMaria João
person.givenNameAntónio
person.givenNameSevero
person.givenNameMario
person.identifier.ciencia-id8710-9DAF-D98C
person.identifier.ciencia-idC31B-B4A0-9BFD
person.identifier.ciencia-idAF15-7000-7C9F
person.identifier.ciencia-id931F-151B-1C03
person.identifier.ciencia-id3117-5106-43BC
person.identifier.orcid0000-0003-2462-307X
person.identifier.orcid0000-0002-7624-7750
person.identifier.orcid0000-0001-9911-5884
person.identifier.orcid0000-0002-3120-4175
person.identifier.orcid0000-0002-6691-9146
person.identifier.orcid0000-0002-7662-4552
person.identifier.orcid0000-0002-0820-226X
person.identifier.orcid0000-0002-7785-6291
person.identifier.orcid0000-0002-8505-9292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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