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Efficacy and Safety of Direct-Acting Oral Anticoagulants Use in Acute Portal Vein Thrombosis Unrelated to Cirrhosis

2017-04Journal article Open access
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dc.contributor.authorNery, F.
dc.contributor.authorValadares, D.
dc.contributor.authorMorais, S.
dc.contributor.authorTeixeira-Gomes, M.
dc.contributor.authorDe Gottardi, A.
dc.date.accessioned2017-09-07T08:45:33Z
dc.date.available2017-09-07T08:45:33Z
dc.date.issued2017-04
dc.description.abstractIn acute portal vein thrombosis (APVT) unrelated to cirrhosis, anticoagulant therapy is classically started with low molecular weight heparin or vitamin K antagonists. New direct-acting oral anticoagulants (DOACs) are used in the treatment of venous thrombosis outside the splanchnic vascular bed, but not in the latter. We report a young female with APVT occurring in a non-cirrhotic liver linked to heterozygosity of factor V-Leiden and prothrombin G20210A gene mutations. Rivaroxaban was started, with total recanalization of the left and partial recanalization of the right portal vein branches, without complications. New DOACs do not need daily subcutaneous injections nor routinely blood coagulation control tests, making its use attractive, eventually increasing patient's compliance. If proved to be safe and effective in the future studies, its use may be extended to PVT treatment. This case shows that rivaroxaban was safe, not only prevented the extension of thrombosis in the portal tract, but also resolved PVT, at least partially.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGastroenterology Res. 2017 Apr;10(2):141-143pt_PT
dc.identifier.doi10.14740/gr806wpt_PT
dc.identifier.issn1918-2805
dc.identifier.issn1918-2813
dc.identifier.urihttp://hdl.handle.net/10400.16/2183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElmer Presspt_PT
dc.relation.publisherversionhttp://www.gastrores.org/index.php/Gastrores/article/view/806pt_PT
dc.subjectAnticoagulationpt_PT
dc.subjectDirect-acting oral anticoagulantspt_PT
dc.subjectPortal vein thrombosispt_PT
dc.titleEfficacy and Safety of Direct-Acting Oral Anticoagulants Use in Acute Portal Vein Thrombosis Unrelated to Cirrhosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCanadapt_PT
oaire.citation.endPage143pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage141pt_PT
oaire.citation.titleGastroenterology Researchpt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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