Repository logo
 
Publication

First trimester aneuploidy screening program for preeclampsia prediction in a portuguese obstetric population

2014Journal article Open access
Simple item page
dc.contributor.authorTeixeira, C.
dc.contributor.authorTejera, E.
dc.contributor.authorMartins, H.
dc.contributor.authorPereira, A.
dc.contributor.authorCosta-Pereira, A
dc.contributor.authorRebelo, I
dc.date.accessioned2015-10-26T14:14:49Z
dc.date.available2015-10-26T14:14:49Z
dc.date.issued2014
dc.description.abstractObjective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (free β -hCG). Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, free β -hCG, CRL, and NT, but not PAPP-A, for prediction of PE. Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.pt_PT
dc.identifier10.1155/2014/435037
dc.identifier.citationObstet Gynecol Int. 2014;2014:435037pt_PT
dc.identifier.doi10.1155/2014/435037
dc.identifier.issn1687-9589
dc.identifier.urihttp://hdl.handle.net/10400.16/1867
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttp://dx.doi.org/10.1155/2014/435037pt_PT
dc.titleFirst trimester aneuploidy screening program for preeclampsia prediction in a portuguese obstetric populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.titleObstetrics and gynecology internationalpt_PT
oaire.citation.volume2014pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
First Trimester Aneuploidy Screening Program for Preeclampsia.pdf
Size:
1.45 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.35 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

SM - Artigos publicados em revistas indexadas na Pubmed/Medline
SOG - Artigos publicados em revistas indexadas na Pubmed/Medline