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Effectiveness of Tocilizumab in the Treatment of Fasciitis with Eosinophilia: Two Case Reports

2020-03-02Journal article Open access
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dc.contributor.authorPinheiro, Maria Guiomar
dc.contributor.authorCosta, Ana Rita
dc.contributor.authorCampar, Ana
dc.contributor.authorMendonça, Teresa
dc.date.accessioned2021-11-22T15:09:50Z
dc.date.available2021-11-22T15:09:50Z
dc.date.issued2020-03-02
dc.description.abstractFasciitis with eosinophilia (FE) is a rare connective tissue disease. Due to its rarity, large-scale studies are lacking, which makes its treatment challenging. Systemic corticosteroids (SCSs) are the cornerstone of treatment; however, additional immunosuppressive drugs (ISDs) are frequently necessary (usually methotrexate). We report 2 patients, for whom an SCS and methotrexate were not a viable long-term option. In the first case, we were unable to taper the SCS dose without symptom relapse, the patient showed only a partial response to methotrexate and presented side effects. The second case never fully responded to the SCS and methotrexate and demonstrated serious SCS adverse effects. Both patients were started on tocilizumab with extremely favourable results, making this drug a potential therapeutic weapon for these patients. Learning points: The treatment of FE is challenging and mainly based on retrospective reviews, open-label trials and case reports, all of which included a small number of patients.Currently, systemic corticosteroids are the mainstay of treatment; however, other ISDs are frequently necessary.Cases showing a favourable clinical response to tocilizumab have recently been described in patients with corticosteroid-refractory disease, suggesting that this drug may potentially become a therapeutic weapon for these patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPinheiro G, Costa AR, Campar A, Mendonça T. Effectiveness of Tocilizumab in the Treatment of Fasciitis with Eosinophilia: Two Case Reports. Eur J Case Rep Intern Med. 2020;7(4):001485. doi:10.12890/2020_001485pt_PT
dc.identifier.doi10.12890/2020_001485pt_PT
dc.identifier.issn2284-2594
dc.identifier.urihttp://hdl.handle.net/10400.16/2598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSMC Mediapt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162578/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEosinophilic fasciitispt_PT
dc.subjectShulman’s diseasept_PT
dc.subjecttocilizumabpt_PT
dc.titleEffectiveness of Tocilizumab in the Treatment of Fasciitis with Eosinophilia: Two Case Reportspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceItalypt_PT
oaire.citation.issue4pt_PT
oaire.citation.titleEuropean Journal of Case Reports in Internal Medicinept_PT
oaire.citation.volume7pt_PT
person.familyNamePinheiro
person.familyNameFernandes Miranda da Costa
person.familyNameCampar
person.familyNameMendonça
person.givenNameMaria Guiomar
person.givenNameAna Rita
person.givenNameAna
person.givenNameTeresa
person.identifier.ciencia-idAE17-7093-C7BC
person.identifier.ciencia-idB114-D73D-99FF
person.identifier.orcid0000-0003-1497-1054
person.identifier.orcid0000-0001-5031-6204
person.identifier.orcid0000-0002-3951-8961
person.identifier.orcid0000-0003-2355-4623
person.identifier.scopus-author-id57194153375
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationae5810a4-751a-42d0-802f-1bb0e17e0032
relation.isAuthorOfPublication84d36115-6e9c-4684-b891-503a5f9ee92d
relation.isAuthorOfPublication1e019293-8ead-400e-a584-9d14eaa2bc4c
relation.isAuthorOfPublicationa2223a17-1f67-4447-b77b-3ea171ee172f
relation.isAuthorOfPublication.latestForDiscoveryae5810a4-751a-42d0-802f-1bb0e17e0032

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