Repository logo
 
Publication

Clinical effectiveness of Enneking appropriate versus Enneking inappropriate procedure in patients with primary osteosarcoma of the spine: a systematic review with meta-analysis

2020Journal article Open access
Simple item page
dc.contributor.authorPombo, Bruno
dc.contributor.authorCristina Ferreira, Ana
dc.contributor.authorCardoso, Pedro
dc.contributor.authorOliveira, António
dc.date.accessioned2021-11-23T14:08:34Z
dc.date.available2021-11-23T14:08:34Z
dc.date.issued2020
dc.description.abstractPurpose: Primary osteosarcoma of the spine is a rare osseous tumour. En bloc resection, in contrast to intralesional resection, is the only procedure able to provide Enneking appropriate (EA) margins, which has improved local control and survival of patients with primary osteosarcoma of the spine. The objective of this study is to compare the risk of local recurrence, metastases development and survival in patients with primary osteosarcoma of the spine submitted to Enneking appropriate (EA) and Enneking inappropriate (EI) procedures. Methods: A systematic search was performed on EBSCO, PubMed and Web of Science, between 1966 and 2018, to identify studies evaluating patients submitted to resection of primary osteosarcoma of the spine. Two reviewers independently assessed all reports. The outcomes were local recurrence, metastases development and survival at 12, 24 and 60 months. Results: Five studies (108 patients) were included for systematic review. These studies support the conclusion that EA procedure has a lower local recurrence rate (RR 0.33, 95% CI 0.17-0.66), a lower metastases development rate (RR 0.39, 95% CI 0.17-0.89) and a higher survival rate at 24 months (RR 1.78, 95% CI 1.24-2.55) and 60 months (RR 1.97, 95% CI 1.14-3.42) of follow-up; however, at 12 months, there is a non-significant difference. Conclusions: EA procedure increases the ratio of remission and survival after 24 months of follow-up. Multidisciplinary oncologic groups should weigh the morbidity of an en bloc resection, knowing that in the first year the probability of survival is the same for EA and EI procedures. These slides can be retrieved under Electronic Supplementary Material.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPombo B, Cristina Ferreira A, Cardoso P, Oliveira A. Clinical effectiveness of Enneking appropriate versus Enneking inappropriate procedure in patients with primary osteosarcoma of the spine: a systematic review with meta-analysis. Eur Spine J. 2020;29(2):238-247. doi:10.1007/s00586-019-06099-7pt_PT
dc.identifier.doi10.1007/s00586-019-06099-7pt_PT
dc.identifier.issn0940-6719
dc.identifier.issn1432-0932
dc.identifier.urihttp://hdl.handle.net/10400.16/2622
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer-Verlagpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs00586-019-06099-7pt_PT
dc.subjectEnneking marginspt_PT
dc.subjectLocal recurrencept_PT
dc.subjectMetastatic diseasept_PT
dc.subjectOsteosarcomapt_PT
dc.subjectPrimary spine tumourspt_PT
dc.subjectSurvivalpt_PT
dc.titleClinical effectiveness of Enneking appropriate versus Enneking inappropriate procedure in patients with primary osteosarcoma of the spine: a systematic review with meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceGermanypt_PT
oaire.citation.endPage247pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage238pt_PT
oaire.citation.titleEuropean Spine Journalpt_PT
oaire.citation.volume29pt_PT
person.familyNamePombo
person.familyNameCardoso
person.givenNameBruno
person.givenNamePedro
person.identifier.ciencia-id9E15-80CD-3DB9
person.identifier.orcid0000-0002-6337-2368
person.identifier.orcid0000-0002-5892-9424
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication45508d0a-21f2-4209-97ab-be5a5aa933f3
relation.isAuthorOfPublication476ed503-c5f5-4114-86b1-a8e107d2f7bd
relation.isAuthorOfPublication.latestForDiscovery476ed503-c5f5-4114-86b1-a8e107d2f7bd

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pombo-2020-Clinical-effectiveness-of-enneking-.pdf
Size:
1022.79 KB
Format:
Adobe Portable Document Format
Download

Collections

SO - Artigos publicados em revistas indexadas na Pubmed/Medline