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Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational study

2020Journal article Open access
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dc.contributor.authorNunes-Carneiro, Diogo
dc.contributor.authorMadanelo, Mariana
dc.contributor.authorSilva, Filipa
dc.contributor.authorPestana, Nicole
dc.contributor.authorRibeiro, Catarina
dc.contributor.authorGil‐Sousa, Diogo
dc.contributor.authorMartins, La Salete
dc.contributor.authorAlmeida, Manuela
dc.contributor.authorDias, Leonidio
dc.contributor.authorJ, Malheiro
dc.contributor.authorCavadas, Vítor
dc.contributor.authorCastro‐Henriques, Antonio
dc.contributor.authorFraga, Avelino
dc.contributor.authorSilva-Ramos, Miguel
dc.date.accessioned2022-07-14T14:22:57Z
dc.date.available2022-07-14T14:22:57Z
dc.date.issued2020
dc.description.abstractThe donors' estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGFR change from 1 to 4 years postdonation evaluated by a linear mixed model. Comparing RKV/W tertiles (T1, T2, T3), RKV/W was a good predictor of 1-year eGFR which was significantly better in T3 donors. Gender, predonation eGFR, and RKV/W were independent predictors of eGFR at 1-year. In a subgroup with predonation eGFR < 90mL/min/1.73 m2 , a significant prediction of eGFR < 60mL/min/1.73 m2 was detected in males with RKV/W ≤ 2.51cm3 /kg. Annual eGFR (ml/min/year) change from 1 to 4 years was + 0.77. RKV/W divided by tertiles (T1-T3) was the only significant predictor: T2 and T3 donors had an annual eGFR improvement opposing to T1. RKV/W was a good predictor of eGFR at 1 year, independently from predonation eGFR. A higher RKV/W was associated with improved eGFR at 1 year. A decline in eGFR on the four years after surgery was only noticeable in donors with RKV/W ≤ 2.13cm3 /kg.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes-Carneiro D, Madanelo M, Silva F, et al. Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid-term renal function after living-donor nephrectomy - a retrospective observational study. Transpl Int. 2020;33(10):1262-1273. doi:10.1111/tri.13683pt_PT
dc.identifier.doi10.1111/tri.13683pt_PT
dc.identifier.issn0934-0874
dc.identifier.issn1432-2277
dc.identifier.urihttp://hdl.handle.net/10400.16/2725
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/tri.13683pt_PT
dc.subjectkidney volumept_PT
dc.subjectliving donorpt_PT
dc.subjectnephrectomypt_PT
dc.subjecttransplantationpt_PT
dc.titleRemaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage1273pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1262pt_PT
oaire.citation.titleTransplant Internationalpt_PT
oaire.citation.volume33pt_PT
person.familyNameNunes-Carneiro
person.familyNameMadanelo
person.familyNameMartins
person.familyNamealmeida
person.familyNamedias
person.familyNameMalheiro
person.familyNameCavadas
person.familyNameFerreira
person.familyNameSilva-Ramos
person.givenNameDiogo
person.givenNameMariana
person.givenNameLa Salete
person.givenNamemanuela
person.givenNameleonidio
person.givenNameJorge
person.givenNameVítor
person.givenNameAvelino
person.givenNameMiguel
person.identifier1911437
person.identifier1861404
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person.identifier.orcid0000-0001-8105-0816
person.identifier.orcid0000-0002-2999-0963
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person.identifier.ridK-6320-2013
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person.identifier.scopus-author-id56207848700
person.identifier.scopus-author-id26434404600
person.identifier.scopus-author-id57198382184
person.identifier.scopus-author-id22952009900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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