Publication
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?
| dc.contributor.author | Leal Moreira, Carla | |
| dc.contributor.author | Cunha, Liliana | |
| dc.contributor.author | Correia, Sofia | |
| dc.contributor.author | Silva, Filipa | |
| dc.contributor.author | Castro, Ana | |
| dc.contributor.author | Tavares, Joana Manuel | |
| dc.contributor.author | Carvalho, Maria João | |
| dc.contributor.author | Oliveira, José Carlos | |
| dc.contributor.author | Santos, Maria Olivia | |
| dc.contributor.author | Cabrita, Antonio | |
| dc.contributor.author | Rodrigues, Anabela | |
| dc.date.accessioned | 2022-01-11T15:34:03Z | |
| dc.date.available | 2022-01-11T15:34:03Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bioimpedance assessment of 52 stable peritoneal dialysis patients. Minimal residual renal function was defined as > 2mL/min/1.73m2. Results: Serum cystatin C was not significantly associated with peritoneal or urinary cystatin C excretion. Negative correlation of cystatin C with normalized protein catabolic rate (rho -0.33, p = 0.02) and a trend towards positive correlation with relative body fat (rho 0.27, p = 0.05) were not independent from residual renal function. Cystatin C was not significantly associated with cardiovascular disease (p = 0.28), nor with glycated hemoglobin (p = 0.19) or c-reactive protein (p = 0.56). In the multivariate model, both age and diabetes were the strongest predictors of cardiovascular disease (odds ratio 1.09, p = 0.029 and odds ratio 29.95, p = 0.016, respectively), while relative body fat was negatively associated with cardiovascular disease (p = 0.038); neither cystatin C (p = 0.096) nor minimal residual renal function (p = 0.756) reached a significant association with cardiovascular disease. Conclusions: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function. | pt_PT |
| dc.description.abstract | Introdução:: Tem sido sugerido que os níveis de cistatina C são modificados pela obesidade e inflamação. Além disso, a cistatina C tem sido associada a eventos cardiovasculares e desfechos de mortalidade. Objetivo:: Estudar a associação da cistatina C com o perfil metabólico e doença cardiovascular de pacientes em diálise peritoneal. Métodos:: Os dados coletados incluíram avaliação clínica, laboratorial e de bioimpedância múltipla de 52 pacientes estáveis em diálise peritoneal. A função renal residual mínima foi definida como > 2mL/min/1,73m2. Resultados:: A cistatina C sérica não esteve significativamente associada à excreção peritoneal ou urinária. A correlação negativa da cistatina C com a taxa catabólica protéica normalizada (rho -0,33, p = 0,02) e uma tendência de correlação positiva com a gordura corporal relativa (rho 0,27, p = 0,05) não foram independentes da função renal residual. A cistatina C não se associou significativamente à doença cardiovascular (p = 0,28), nem com hemoglobina glicada (p = 0,19) ou proteína C reativa (p = 0,56). No modelo multivariado, idade e diabetes foram os mais fortes preditores de doença cardiovascular (razões de probabilidade 1,09, p = 0,029 e 29,95, p = 0,016, respectivamente) enquanto a gordura corporal relativa se associou negativamente à doença cardiovascular (p = 0,038). A cistatina C não se associou significativamente com doença cardiovascular (p = 0,096), tampouco a função residual mínima (p = 0,756). Conclusão:: Neste grupo de pacientes em diálise peritoneal, a cistatina C não se correlacionou com o estado metabólico ou inflamatório, nem com doença cardiovascular, após ajuste para função renal residual. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Moreira CL, Cunha L, Correia S, et al. Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?. J Bras Nefrol. 2020;42(1):31-37. doi:10.1590/2175-8239-JBN-2019-0007 | pt_PT |
| dc.identifier.doi | 10.1590/2175-8239-jbn-2019-0007 | pt_PT |
| dc.identifier.issn | 0101-2800 | |
| dc.identifier.issn | 2175-8239 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/2656 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Sociedade Brasileira de Nefrologia | pt_PT |
| dc.relation.publisherversion | https://www.scielo.br/j/jbn/a/3FhD9xWBMPqv3hjNDXRhdpw/?lang=en# | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Cystatin C | pt_PT |
| dc.subject | Cardiovascular Diseases | pt_PT |
| dc.subject | Peritoneal Dialysis | pt_PT |
| dc.title | Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? | pt_PT |
| dc.title.alternative | Teria a Cistatina C um papel como substituto metabólico na diálise peritoneal além de sua associação com a função renal residual? | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Brazil | pt_PT |
| oaire.citation.endPage | 37 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 31 | pt_PT |
| oaire.citation.title | Brazilian Journal of Nephrology | pt_PT |
| oaire.citation.volume | 42 | pt_PT |
| person.familyName | Leal Moreira | |
| person.familyName | Cunha | |
| person.familyName | Correia | |
| person.familyName | Silva | |
| person.familyName | Castro | |
| person.familyName | Tavares | |
| person.familyName | Carvalho | |
| person.familyName | Oliveira | |
| person.familyName | Santos | |
| person.familyName | Cabrita | |
| person.familyName | Soares Rodrigues | |
| person.givenName | Carla | |
| person.givenName | Liliana | |
| person.givenName | Sofia | |
| person.givenName | Filipa | |
| person.givenName | Ana | |
| person.givenName | Joana Manuel | |
| person.givenName | Maria João | |
| person.givenName | José Carlos | |
| person.givenName | Maria Olivia | |
| person.givenName | Antonio | |
| person.givenName | Anabela | |
| person.identifier | 806053 | |
| person.identifier.ciencia-id | C012-7D92-E4A3 | |
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| person.identifier.orcid | 0000-0002-7913-4460 | |
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| person.identifier.orcid | 0000-0001-8818-2141 | |
| person.identifier.rid | K-5226-2013 | |
| person.identifier.scopus-author-id | 57211840457 | |
| person.identifier.scopus-author-id | 7202269896 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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