Donor-derived fatal hyperinfection strongyloidiasis in renal transplant recipient

Cipriano, Ana; Dias, Rita; Cleto Marinho, Ricardo; Correia, Sofia; Lopes, Virgínia; Cardoso, Teresa; Aragão, Irene

http://hdl.handle.net/10400.16/2644

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Authors

Cipriano, Ana

Dias, Rita

Cleto Marinho, Ricardo

Abstract(s)

Strongyloides stercoralis is a nematode, endemic in tropical and subtropical areas. Strongyloidiasis has been reported in recipients of hematopoietic stem cells, kidney, liver, heart, intestine, and pancreas, eventually presenting as disseminated strongyloidiasis and hyperinfection syndrome (SHS) which is associated with high mortality. We report one case of a recent renal transplant recipient, who presented with gastrointestinal and respiratory symptoms, evolving into shock. The identification of Strongyloides stercoralis in the bronchoalveolar lavage (BAL) lead us to the diagnosis of SHS. Treatment with subcutaneous ivermectin was started, however the patient did not survive. Retrospective serum donor analysis allowed us to identify the donor as the source of infection.

Keywords

Donor-derived infection Kidney transplantation Strongyloides hyperinfection syndrome Strongyloides stercoralis Subcutaneus irvemectin

URI

http://hdl.handle.net/10400.16/2644

Citation

Cipriano A, Dias R, Marinho R, et al. Donor-derived fatal hyperinfection strongyloidiasis in renal transplant recipient. IDCases. 2020;19:e00703. doi:10.1016/j.idcr.2020.e00703