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Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study

2021Journal article Open access
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dc.contributor.authorAlão, Sílvia
dc.contributor.authorConceição, João
dc.contributor.authorDores, Jorge
dc.contributor.authorSantos, Lèlita
dc.contributor.authorAraújo, Francisco
dc.contributor.authorPape, Estevão
dc.contributor.authorReis, Mónica
dc.contributor.authorChipepo, Árcia
dc.contributor.authorNascimento, Edite
dc.contributor.authorBaptista, Ana
dc.contributor.authorPires, Vanessa
dc.contributor.authorMarques, Carlos
dc.contributor.authorLages, Adriana De Sousa
dc.contributor.authorPelicano-Romano, João
dc.contributor.authorde Jesus, Paula M.
dc.date.accessioned2022-11-10T10:32:02Z
dc.date.available2022-11-10T10:32:02Z
dc.date.issued2021
dc.description.abstractBackground: We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted to a hospital ward, and calculate the prevalence of risk factors for hypoglycemia and diabetic complications. Methods: In this cross-sectional, multicentered study, the observational data was collected by physicians from patient's hospitalization to discharge/death. Statistical tests were 2-tailed considering 5% significance level. Results: There were 646 ward admissions due to hyperglycemic emergencies and 176 hypoglycemic episodes with a ratio hypoglycemia/hyperglycemia 0.27 for all DM patients. In T2DM patients the ratio was 0.38. These were mainly female (55.1%), functionally dependent (61.4%) and retired/disabled (73.1%). Median age was 75 years and median duration of disease 11 years. Half the patients were on insulin-based therapy and 30.1% on secretagogue-based therapy. Approximately 57% of patients needed occasional/full assistance to manage the disease. The most frequent risk factor for hypoglycemia was polypharmacy (85.0%). Hypoglycemia in the 12 months before admission was higher in insulin-based therapy patients (66.1%; p = 0.001). Conclusions: Hyperglycemic emergencies are the most frequent cause of hospitalization in Portugal, although severe hypoglycemic events represent a health and social problem in elderly/frail patients. There is still the need to optimize therapy in terms of the potential for hypoglycemia in this patient group and a review of anti-hyperglycemic agents to add on to insulin.pt_PT
dc.description.sponsorshipThis work was supported by Merck Sharp & Dohme (MSD) Portugal [MK0431–854]. The study was scientifically promoted by the Portuguese Society of Diabetology (Sociedade Portuguesa de Diabetologia), Portuguese Society of Endocrinology, Diabetes and Metabolism (Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo) and Portuguese Society of Internal Medicine (Sociedade Portuguesa de Medicina Interna).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlão S, Conceição J, Dores J, et al. Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study. Clin Diabetes Endocrinol. 2021;7(1):2. doi:10.1186/s40842-020-00114-3pt_PT
dc.identifier.doi10.1186/s40842-020-00114-3pt_PT
dc.identifier.issn2055-8260
dc.identifier.urihttp://hdl.handle.net/10400.16/2743
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttps://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-020-00114-3pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDiabetespt_PT
dc.subjectHypoglycemic episodespt_PT
dc.subjectInpatientspt_PT
dc.titleHypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.titleClinical Diabetes and Endocrinologypt_PT
oaire.citation.volume7pt_PT
person.familyNameDores
person.givenNameJorge
person.identifier.orcid0000-0001-9883-3809
person.identifier.scopus-author-id6508177324
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4c215b73-6e1f-4d00-80ec-1ab674b7e89a
relation.isAuthorOfPublication.latestForDiscovery4c215b73-6e1f-4d00-80ec-1ab674b7e89a

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