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Portuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design – A population-based study

2023Journal article Open access
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dc.contributor.authorBaptista, Rui
dc.contributor.authorSilva Cardoso, José
dc.contributor.authorCanhão, Helena
dc.contributor.authorMaria Rodrigues, Ana
dc.contributor.authorKislaya, Irina
dc.contributor.authorFranco, Fátima
dc.contributor.authorBernardo, Filipa
dc.contributor.authorPimenta, Joana
dc.contributor.authorMendes, Lígia
dc.contributor.authorGonçalves, Sara
dc.contributor.authorTeresa Timóteo, Ana
dc.contributor.authorAndrade, Aurora
dc.contributor.authorMoura, Brenda
dc.contributor.authorFonseca, Cândida
dc.contributor.authorAguiar, Carlos
dc.contributor.authorBrito, Dulce
dc.contributor.authorFerreira, Jorge
dc.contributor.authorFilipe Azevedo, Luís
dc.contributor.authorPeres, Marisa
dc.contributor.authorSantos, Paulo
dc.contributor.authorMoraes Sarmento, Pedro
dc.contributor.authorCernadas, Rui
dc.contributor.authorSantos, Mario
dc.contributor.authorFontes-Carvalho, Ricardo
dc.contributor.authorCampos Fernandes, Adalberto
dc.contributor.authorMartinho, Hugo
dc.contributor.authorGonzález-Juanatey, José Ramon
dc.contributor.authorFilipe Pereira, Luís
dc.contributor.authorGil, Victor
dc.contributor.authorRaquel Marques, Cláudia
dc.contributor.authorAlmeida, Mário
dc.contributor.authorPardal, Marisa
dc.contributor.authorBarbosa, Veneranda
dc.contributor.authorGavina, Cristina
dc.date.accessioned2024-07-23T11:07:13Z
dc.date.available2024-07-23T11:07:13Z
dc.date.issued2023
dc.description.abstractIntroduction and objectives: Current epidemiological data on heart failure (HF) in Portugal derives from studies conducted two decades ago. The main aim of this study is to determine HF prevalence in the Portuguese population. Using current standards, this manuscript aims to describe the methodology and research protocol applied. Methods: The Portuguese Heart Failure Prevalence Observational Study (PORTHOS) is a large, three-stage, population-based, nationwide, cross-sectional study. Community-dwelling citizens aged 50 years and older will be randomly selected via stratified multistage sampling. Eligible participants will be invited to attend a screening visit at a mobile clinic for HF symptom assessment, anthropomorphic assessment, N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing, one-lead electrocardiogram (ECG) and a sociodemographic and health-related quality of life questionnaire (EQ-5D). All subjects with NT-proBNP ≥125 pg/mL or with a prior history of HF will undergo a diagnostic confirmatory assessment at the mobile clinic composed of a 12-lead ECG, comprehensive echocardiography, HF questionnaire (KCCQ) and blood sampling. To validate the screening procedure, a control group will undergo the same diagnostic assessment. Echocardiography results will be centrally validated, and HF diagnosis will be established according to the European Society of Cardiology HF guidelines. A random subsample of patients with an equivocal HF with preserved ejection fraction diagnosis based on the application of the Heart Failure Association preserved ejection fraction diagnostic algorithm will be invited to undergo an exercise echocardiography. Conclusions: Through the application of current standards, appropriate methodologies, and a strong research protocol, the PORTHOS study will determine the prevalence of HF in mainland Portugal and enable a comprehensive characterization of HF patients, leading to a better understanding of their clinical profile and health-related quality of life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBaptista R, Silva Cardoso J, Canhão H, et al. Portuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design - A population-based study. Rev Port Cardiol. 2023;42(12):985-995. doi:10.1016/j.repc.2023.10.004pt_PT
dc.identifier.doi10.1016/j.repc.2023.10.004pt_PT
dc.identifier.issn0870-2551
dc.identifier.issn2174-2030
dc.identifier.urihttp://hdl.handle.net/10400.16/3020
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.repc.2023.10.004pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEpidemiologiapt_PT
dc.subjectEpidemiologypt_PT
dc.subjectHeart failurept_PT
dc.subjectInsuficiência cardíacapt_PT
dc.subjectPORTHOSpt_PT
dc.subjectPortugalpt_PT
dc.subjectPrevalencept_PT
dc.subjectPrevalênciapt_PT
dc.subjectQualidade de vidapt_PT
dc.subjectQuality of lifept_PT
dc.titlePortuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design – A population-based studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpt_PT
oaire.citation.endPage995pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage985pt_PT
oaire.citation.titleRevista Portuguesa de Cardiologiapt_PT
oaire.citation.volume42pt_PT
person.familyNameSantos
person.givenNameMario
person.identifier.ciencia-idCB17-AD56-DE37
person.identifier.orcid0000-0002-4509-0260
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7cf7a05b-3af4-4eaf-b3b5-9021cb7a2629
relation.isAuthorOfPublication.latestForDiscovery7cf7a05b-3af4-4eaf-b3b5-9021cb7a2629

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