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Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles

2020-05-29Journal article Open access
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dc.contributor.authorCastanheira De Oliveira, Manuel
dc.contributor.authorCaires, Hugo R.
dc.contributor.authorOliveira, Maria J
dc.contributor.authorFraga, Avelino
dc.contributor.authorVasconcelos, M. Helena
dc.contributor.authorRibeiro, Ricardo
dc.date.accessioned2021-11-12T12:48:28Z
dc.date.available2021-11-12T12:48:28Z
dc.date.issued2020-05-29
dc.description.abstractExtracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathological conditions, such as cancer. In the multistep process of cancer progression, EVs act at different levels, from stimulation of neoplastic transformation, proliferation, promotion of angiogenesis, migration, invasion, and formation of metastatic niches in distant organs, to immune escape and therapy resistance. Moreover, as products of their parental cells, reflecting their genetic signatures and phenotypes, EVs hold great promise as diagnostic and prognostic biomarkers. Importantly, their potential to overcome the current limitations or the present diagnostic procedures has created interest in bladder cancer (BCa). Indeed, cystoscopy is an invasive and costly technique, whereas cytology has poor sensitivity for early staged and low-grade disease. Several urine-based biomarkers for BCa were found to overcome these limitations. Here, we review their potential advantages and downfalls. In addition, recent literature on the potential of EVs to improve BCa management was reviewed and discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira MC, Caires HR, Oliveira MJ, Fraga A, Vasconcelos MH, Ribeiro R. Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles. Cancers (Basel). 2020;12(6):1400. Published 2020 May 29. doi:10.3390/cancers12061400pt_PT
dc.identifier.doi10.3390/cancers12061400pt_PT
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.16/2538
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/12/6/1400pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectbiomarkerspt_PT
dc.subjectbladder cancerpt_PT
dc.subjectextracellular vesiclespt_PT
dc.subjectliquid biopsypt_PT
dc.subjectmicrovesiclespt_PT
dc.subjecturothelial cancerpt_PT
dc.titleUrinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesiclespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1400pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume12pt_PT
person.familyNameCastanheira de Oliveira
person.familyNameCaires
person.familyNameOliveira
person.familyNameFerreira
person.familyNameVasconcelos
person.givenNameManuel
person.givenNameHugo R.
person.givenNameMaria José
person.givenNameAvelino
person.givenNameM. Helena
person.identifier232344
person.identifier131294
person.identifier.ciencia-idE116-624F-8B9C
person.identifier.ciencia-idB41B-88E4-A903
person.identifier.ciencia-idFA10-F55F-3D4B
person.identifier.ciencia-id4516-5451-90E9
person.identifier.orcid0000-0002-7884-5121
person.identifier.orcid0000-0001-7657-7410
person.identifier.orcid0000-0002-0724-0272
person.identifier.orcid0000-0002-2999-0963
person.identifier.orcid0000-0002-7801-4643
person.identifier.ridK-3275-2013
person.identifier.scopus-author-id56644725700
person.identifier.scopus-author-id35426366800
person.identifier.scopus-author-id57198382184
person.identifier.scopus-author-id7006465065
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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