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If, When, and How to Use Rifampin in Acute Staphylococcal Periprosthetic Joint Infections, a Multicentre Observational Study

dc.contributor.authorBeldman, Mark
dc.contributor.authorLöwik, Claudia
dc.contributor.authorSoriano, Alex
dc.contributor.authorAlbiach, Laila
dc.contributor.authorZijlstra, Wierd P
dc.contributor.authorKnobben, Bas A S
dc.contributor.authorJutte, Paul
dc.contributor.authorSousa, Ricardo
dc.contributor.authorCarvalho, André
dc.contributor.authorGoswami, Karan
dc.contributor.authorParvizi, Javad
dc.contributor.authorBelden, Katherine A
dc.contributor.authorWouthuyzen-Bakker, Marjan
dc.date.accessioned2023-10-24T11:12:15Z
dc.date.available2023-10-24T11:12:15Z
dc.date.issued2021-11
dc.description.abstractBackground: Rifampin is generally advised in the treatment of acute staphylococcal periprosthetic joint infections (PJI). However, if, when, and how to use rifampin remains a matter of debate. We evaluated the outcome of patients treated with and without rifampin, and analyzed the influence of timing, dose and co-antibiotic. Methods: Acute staphylococcal PJIs treated with surgical debridement between 1999 and 2017, and a minimal follow-up of 1 year were evaluated. Treatment failure was defined as the need for any further surgical procedure related to infection, PJI-related death or the need for suppressive antimicrobial treatment. Results: A total of 669 patients were analyzed. Treatment failure was 32.2% (131/407) in patients treated with rifampin and 54.2% (142/262) in whom rifampin was withheld (P < .001). The most prominent effect of rifampin was observed in knees (treatment failure 28.6% versus 63.9%, respectively, P < .001). The use of rifampin was an independent predictor of treatment success in the multi-variate analysis (OR 0.30, 95% CI 0.20 - 0.45). In the rifampin group, the use of a co-antibiotic other than a fluoroquinolone or clindamycin (OR 10.1, 95% CI 5.65 - 18.2) and the start of rifampin within 5 days after surgical debridement (OR 1.96, 95% CI 1.08 - 3.65) were predictors of treatment failure. The dosing of rifampin had no effect on outcome.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBeldman M, Löwik C, Soriano A, et al. If, When, and How to Use Rifampin in Acute Staphylococcal Periprosthetic Joint Infections, a Multicentre Observational Study [published correction appears in Clin Infect Dis. 2022 May 30;74(10):1890]. Clin Infect Dis. 2021;73(9):1634-1641. doi:10.1093/cid/ciab426pt_PT
dc.identifier.doi10.1093/cid/ciab426pt_PT
dc.identifier.issn1058-4838
dc.identifier.issn1537-6591
dc.identifier.urihttp://hdl.handle.net/10400.16/2846
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/cid/article/73/9/1634/6273129?login=falsept_PT
dc.subjectacutept_PT
dc.subjectfailurept_PT
dc.subjectperiprosthetic joint infectionpt_PT
dc.subjectrifampinpt_PT
dc.subjectstaphylococcipt_PT
dc.titleIf, When, and How to Use Rifampin in Acute Staphylococcal Periprosthetic Joint Infections, a Multicentre Observational Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage1641pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1634pt_PT
oaire.citation.titleClinical Infectious Diseasespt_PT
oaire.citation.volume73pt_PT
person.familyNameSousa
person.givenNameRicardo
person.identifier.ciencia-id8C18-816F-6E4A
person.identifier.orcid0000-0003-4293-7347
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2f21d3c0-c752-499f-9bcc-d87d9fd31d5c
relation.isAuthorOfPublication.latestForDiscovery2f21d3c0-c752-499f-9bcc-d87d9fd31d5c

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