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Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema: Exploratory Retrospective Analysis

2021Journal article Open access
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dc.contributor.authorPessoa, Bernardete
dc.contributor.authorMalheiro, Luisa
dc.contributor.authorCarneiro, Inês
dc.contributor.authorMonteiro, Sílvia
dc.contributor.authorCoelho, João
dc.contributor.authorCoelho, Constança
dc.contributor.authorFigueira, João P
dc.contributor.authorMeireles, Angelina
dc.contributor.authorBeirão, João
dc.date.accessioned2023-10-23T08:29:22Z
dc.date.available2023-10-23T08:29:22Z
dc.date.issued2021
dc.description.abstractAim: To evaluate the efficacy of switching from bevacizumab to ranibizumab or aflibercept in eyes with diabetic macular edema (DME) unresponsive to bevacizumab. Methods: Single-center retrospective comparative study of patients with DME unresponsive to intravitreal bevacizumab that was switched to ranibizumab or aflibercept. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were analysed prior to and 4 months after the switch. Ocular coherence tomography (OCT) biomarkers were also analysed. Results: Fifty-six eyes from 40 patients were included in the study, 33 eyes switched to ranibizumab and 23 to aflibercept. A significant median CFT decrease was observed in both groups (p<0.001), with no between-group differences. BCVA gain was only significant in the ranibizumab group (p<0.001). None of the pre-baseline or baseline parameters were associated with the response to ranibizumab or aflibercept. Conclusion: In persistent DME unresponsive to bevacizumab, both anatomical and functional improvements were observed with ranibizumab whereas aflibercept only showed an anatomical improvement. Clinicaltrials.gov NCT04018833.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPessoa B, Malheiro L, Carneiro I, et al. Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema: Exploratory Retrospective Analysis. Clin Ophthalmol. 2021;15:253-260. doi:10.2147/OPTH.S280644pt_PT
dc.identifier.doi10.2147/OPTH.S280644pt_PT
dc.identifier.issn1177-5467
dc.identifier.issn1177-5483
dc.identifier.urihttp://hdl.handle.net/10400.16/2829
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/intravitreal-ranibizumab-or-aflibercept-after-bevacizumab-in-diabetic--peer-reviewed-fulltext-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectafliberceptpt_PT
dc.subjectbevacizumabpt_PT
dc.subjectdiabetic macular edemapt_PT
dc.subjectranibizumabpt_PT
dc.subjectrefractorypt_PT
dc.titleIntravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema: Exploratory Retrospective Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage260pt_PT
oaire.citation.startPage253pt_PT
oaire.citation.titleClinical Ophthalmologypt_PT
oaire.citation.volume15pt_PT
person.familyNamePessoa
person.familyNameMalheiro
person.familyNameMonteiro
person.familyNameCoelho
person.familyNameCoelho
person.familyNameFigueira
person.familyNameMeireles
person.familyNameBeirão
person.givenNameBernardete
person.givenNameLuisa
person.givenNameSílvia
person.givenNameJoão
person.givenNameConstança
person.givenNameJoão P
person.givenNameAngelina
person.givenNameJoão Nuno Melo
person.identifier.ciencia-id0E1B-7EB2-B90F
person.identifier.ciencia-id7515-8385-064B
person.identifier.ciencia-idEF12-4F5F-7831
person.identifier.ciencia-id0214-5233-EE9D
person.identifier.orcid0000-0002-5673-1561
person.identifier.orcid0000-0001-9937-6806
person.identifier.orcid0000-0001-5040-6170
person.identifier.orcid0000-0003-2261-5682
person.identifier.orcid0000-0002-5331-2257
person.identifier.orcid0000-0002-3511-1515
person.identifier.orcid0000-0001-9148-2786
person.identifier.orcid0000-0001-8642-7010
person.identifier.scopus-author-id7005608345
person.identifier.scopus-author-id36647626200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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