Repository logo
 
Publication

Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis

2023-03Journal article Open access
Simple item page
dc.contributor.authorBranco, Patrícia
dc.contributor.authorCalça, Rita
dc.contributor.authorMartins, Ana Rita
dc.contributor.authorMateus, Catarina
dc.contributor.authorJervis, Maria João
dc.contributor.authorGomes, Daniel Pinto
dc.contributor.authorAzeredo-Lopes, Sofia
dc.contributor.authorDe Melo Junior, Antonio Ferreira
dc.contributor.authorSousa, Cátia
dc.contributor.authorCivantos, Ester
dc.contributor.authorMas-Fontao, Sebastian
dc.contributor.authorGaspar, Augusta
dc.contributor.authorRamos, Sância
dc.contributor.authorMorello, Judit
dc.contributor.authorNolasco, Fernando
dc.contributor.authorRodrigues, Anabela
dc.contributor.authorPereira, Sofia Azeredo
dc.date.accessioned2024-07-23T10:12:57Z
dc.date.available2024-07-23T10:12:57Z
dc.date.issued2023-03
dc.description.abstractPeritoneal membrane status, clinical data and aging-related molecules were investigated as predictors of long-term peritoneal dialysis (PD) outcomes. A 5-year prospective study was conducted with the following endpoints: (a) PD failure and time until PD failure, (b) major cardiovascular event (MACE) and time until MACE. A total of 58 incident patients with peritoneal biopsy at study baseline were included. Peritoneal membrane histomorphology and aging-related indicators were assessed before the start of PD and investigated as predictors of study endpoints. Fibrosis of the peritoneal membrane was associated with MACE occurrence and earlier MACE, but not with the patient or membrane survival. Serum α-Klotho bellow 742 pg/mL was related to the submesothelial thickness of the peritoneal membrane. This cutoff stratified the patients according to the risk of MACE and time until MACE. Uremic levels of galectin-3 were associated with PD failure and time until PD failure. This work unveils peritoneal membrane fibrosis as a window to the vulnerability of the cardiovascular system, whose mechanisms and links to biological aging need to be better investigated. Galectin-3 and α-Klotho are putative tools to tailor patient management in this home-based renal replacement therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBranco P, Calça R, Martins AR, et al. Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis. Int J Mol Sci. 2023;24(5):5020. doi:10.3390/ijms24055020pt_PT
dc.identifier.doi10.3390/ijms24055020pt_PT
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.16/3016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
dc.relation.publisherversionhttps://doi.org/10.3390/ijms24055020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcardiovascular toxicitypt_PT
dc.subjectchronic kidney diseasept_PT
dc.subjectgalectin-3pt_PT
dc.subjecturemic toxinspt_PT
dc.subjectα-Klothopt_PT
dc.titleFibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04462%2F2020/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage5020pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSoares Rodrigues
person.givenNameAnabela
person.identifier.ciencia-id651F-A9D2-2136
person.identifier.orcid0000-0001-8818-2141
person.identifier.ridK-5226-2013
person.identifier.scopus-author-id7202269896
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2276a1c5-40fe-41e9-a369-a40049bf81e3
relation.isAuthorOfPublication.latestForDiscovery2276a1c5-40fe-41e9-a369-a40049bf81e3
relation.isProjectOfPublication0975dd56-4220-4dd5-9a42-4291f0c36a90
relation.isProjectOfPublication.latestForDiscovery0975dd56-4220-4dd5-9a42-4291f0c36a90

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Branco-2023-Fibrosis-of-peritoneal-membrane-mol.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

SNEF - Artigos publicados em revistas indexadas na Pubmed/Medline