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New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature

2020-12-22Journal article Open access
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dc.contributor.authorLousa, Irina
dc.contributor.authorReis, Flávio
dc.contributor.authorBeirão, Idalina
dc.contributor.authorAlves, Rui
dc.contributor.authorBelo, Luís
dc.contributor.authorSantos-Silva, Alice
dc.date.accessioned2021-12-09T15:23:52Z
dc.date.available2021-12-09T15:23:52Z
dc.date.issued2020-12-22
dc.description.abstractThe prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality rate continues to be unacceptably high. The biomarkers currently used in clinical practice are considered relevant when there is already significant renal impairment compromising the early use of potentially successful therapeutic interventions. More sensitive and specific biomarkers to detect CKD earlier on and improve patients' prognoses are an important unmet medical need. The aim of this review is to summarize the recent literature on new promising early CKD biomarkers of renal function, tubular lesions, endothelial dysfunction and inflammation, and on the auspicious findings from metabolomic studies in this field. Most of the studied biomarkers require further validation in large studies and in a broad range of populations in order to be implemented into routine CKD management. A panel of biomarkers, including earlier biomarkers of renal damage, seems to be a reasonable approach to be applied in clinical practice to allow earlier diagnosis and better disease characterization based on the underlying etiologic process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLousa I, Reis F, Beirão I, Alves R, Belo L, Santos-Silva A. New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the Literature. Int J Mol Sci. 2020;22(1):43. doi:10.3390/ijms22010043pt_PT
dc.identifier.doi10.3390/ijms22010043pt_PT
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.16/2651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/1/43pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectchronic kidney disease (CKD)pt_PT
dc.subjectendothelial dysfunctionpt_PT
dc.subjectmetabolomicpt_PT
dc.subjectoxidative stresspt_PT
dc.subjecttubular lesionspt_PT
dc.titleNew Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage43pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume22pt_PT
person.familyNameAlmeida Brandão de Melo Beirão
person.givenNameIdalina Maria
person.identifier.ciencia-id591E-1DC4-68EF
person.identifier.orcid0000-0003-3903-0170
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication86b5a4bb-cffa-4307-8a37-ba701f26bca3
relation.isAuthorOfPublication.latestForDiscovery86b5a4bb-cffa-4307-8a37-ba701f26bca3

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