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Folic acid, vitamin B12, and psychotic symptoms among young psychiatric inpatients

2021-06Journal article Open access
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dc.contributor.authorPedro dos Reis, Filipa
dc.contributor.authorDuarte, Luísa
dc.contributor.authorCartaxo, Teresa
dc.contributor.authorSantos, Vítor
dc.date.accessioned2021-11-02T11:43:25Z
dc.date.available2021-11-02T11:43:25Z
dc.date.issued2021-06
dc.description.abstractIntroduction: Folic acid and/or vitamin B12 deficiency are known to be associated with neuropsychiatric disorders. However, the association between serum levels of these molecules and psychotic symptoms is not established. The aim of this study was to investigate the association between folic acid and vitamin B12 serum levels and the presence of psychotic symptoms among child and young adult psychiatric inpatients. Material and Methods: This was a retrospective cohort study of 165 patients under 25 years of age admitted due to psychiatric disorders between 2005 and 2018 and with folic acid and vitamin B12 serum levels assessed during hospitalization. Two groups of patients were defined according to presence or absence of psychotic symptoms. Rehospitalization was also assessed. Results: Folic acid serum levels were significantly lower (p=0.01) in children and young adults hospitalized for psychiatric disorders with psychotic symptoms compared to patients of the same age with acute psychiatric illness without psychotic symptoms. A similar non-significant trend was found for vitamin B12. Rehospitalization rates were also higher in the first group. Conclusion: Results from this study suggest that low folic acid serum levels are associated with psychotic symptoms regardless of the baseline diagnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPedro-dos-Reis F, Duarte L, Cartaxo T, Santos V, Nascer e Crescer - Birth and Growth Medical Journal 2021;30(2): 85-91. doi:10.25753/BirthGrowthMJ.v30.i2.18765pt_PT
dc.identifier.doi10.25753/BirthGrowthMJ.v30.i2.18765pt_PT
dc.identifier.issn2183-9417
dc.identifier.urihttp://hdl.handle.net/10400.16/2522
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Hospitalar Universitário do Portopt_PT
dc.relation.publisherversionhttps://revistas.rcaap.pt/nascercrescer/article/view/18765pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectfolic acidpt_PT
dc.subjectpsychiatric hospitalizationpt_PT
dc.subjectpsychopathologypt_PT
dc.subjectpsychosispt_PT
dc.subjectvitamin B12pt_PT
dc.titleFolic acid, vitamin B12, and psychotic symptoms among young psychiatric inpatientspt_PT
dc.title.alternativeÁcido fólico, vitamina B12 e sintomas psicóticos no internamento psiquiátrico de crianças e jovenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.endPage91pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage85pt_PT
oaire.citation.titleNascer e Crescer - Birth and Growth Medical Journalpt_PT
oaire.citation.volume30pt_PT
person.familyNameReis
person.familyNameRibeiro Duarte
person.familyNameCartaxo
person.familyNameSantos
person.givenNameFilipa
person.givenNameAna Luísa
person.givenNameTeresa
person.givenNameVítor
person.identifier.orcid0000-0001-8562-2826
person.identifier.orcid0000-0003-4192-5563
person.identifier.orcid0000-0001-5440-2863
person.identifier.orcid0000-0003-1945-4339
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9bccb647-f405-42ff-a4f9-588cd54b119d
relation.isAuthorOfPublication469530e5-4c50-48ec-acb4-3e9a3f79ea23
relation.isAuthorOfPublication7eb54568-2d3b-437d-9e12-13dadfa73ce4
relation.isAuthorOfPublication.latestForDiscoverya42d2da3-b22c-4583-8adc-2dc97ad3f3c1

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