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Impact of preformed donor-specific antibodies against HLA class I on kidney graft outcomes: Comparative analysis of exclusively anti-Cw vs anti-A and/or -B antibodies

2016-12-24Journal article Open access
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dc.contributor.authorSantos, S.
dc.contributor.authorMalheiro, J.
dc.contributor.authorTafulo, S.
dc.contributor.authorDias, L.
dc.contributor.authorCarmo, R.
dc.contributor.authorSampaio, S.
dc.contributor.authorCosta, M.
dc.contributor.authorCampos, A.
dc.contributor.authorPedroso, S.
dc.contributor.authorAlmeida, M.
dc.contributor.authorMartins, L.
dc.contributor.authorHenriques, C.
dc.contributor.authorCabrita, A.
dc.date.accessioned2017-07-24T15:17:03Z
dc.date.available2017-07-24T15:17:03Z
dc.date.issued2016-12-24
dc.description.abstractAIM: To analyze the clinical impact of preformed antiHLA-Cw vs antiHLA-A and/or -B donor-specific antibodies (DSA) in kidney transplantation. METHODS: Retrospective study, comparing 12 patients transplanted with DSA exclusively antiHLA-Cw with 23 patients with preformed DSA antiHLA-A and/or B. RESULTS: One year after transplantation there were no differences in terms of acute rejection between the two groups (3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1). At one year, eGFR was not significantly different between groups (median 59 mL/min in DSA-Cw group, compared to median 51 mL/min in DSA-A-B group, P = 0.192). Moreover, kidney graft survival was similar between groups at 5-years (100% in DSA-Cw group vs 91% in DSA-A-B group, P = 0.528). The sole independent predictor of antibody mediated rejection (AMR) incidence was DSA strength (HR = 1.07 per 1000 increase in MFI, P = 0.034). AMR was associated with shortened graft survival at 5-years, with 75% and 100% grafts surviving in patients with or without AMR, respectively (Log-rank P = 0.005). CONCLUSION: Our data indicate that DSA-Cw are associated with an identical risk of AMR and impact on graft function in comparison with "classical" class I DSA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWorld J Transplant. 2016 Dec 24;6(4):689-696pt_PT
dc.identifier.doi10.5500/wjt.v6.i4.689pt_PT
dc.identifier.issn2220-3230
dc.identifier.urihttp://hdl.handle.net/10400.16/2161
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBaishideng Publishing Grouppt_PT
dc.relation.publisherversionhttps://www.wjgnet.com/2220-3230/full/v6/i4/689.htmpt_PT
dc.subjectAnti human leukocyte antigen class Ipt_PT
dc.subjectAntiHLA-Cw antibodiespt_PT
dc.subjectAntibody-mediated rejectionpt_PT
dc.subjectDonor-specific antibodiespt_PT
dc.subjectGraft survivalpt_PT
dc.subjectSolid-phase immunoassayspt_PT
dc.titleImpact of preformed donor-specific antibodies against HLA class I on kidney graft outcomes: Comparative analysis of exclusively anti-Cw vs anti-A and/or -B antibodiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage696pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage689pt_PT
oaire.citation.titleWorld Journal of Transplantationpt_PT
oaire.citation.volume6pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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