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Publication
Cross-allergy between penicillins and cephalosporins: a paradigm shift
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Authors
Advisor(s)
Abstract(s)
Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy.
The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity.
Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.
Description
Keywords
cephalosporin cross-reactivity penicillin side chain
Citation
Nascer e Crescer - Birth and Growth Medical Journal 2022;31(1):31-37. doi:10.25753/BirthGrowthMJ.v31.i1.20898
Publisher
Centro Hospitalar Universitário do Porto