Chronic granulomatous disease as a risk factor for cutaneous lupus in childhood

Carvalho, S.; Machado, S.; Sampaio, R.; Guedes, M.; Vasconcelos, J.; Semedo, D.; Selores, M.

http://hdl.handle.net/10400.16/2163

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Abstract(s)

Chronic granulomatous disease (CGD) is a primaryimmunodeficiency disorder that affects the phagocyticcells of the innate immune system. It is characterizedby recurrent or persistent infections with granulomaformation. Lupus-like lesions have been reported incarriers of CGD and less frequently, in patients withCGD. Immunological study in these patients areusually negative. We describe the case of an 8-yearoldboy with CGD who developed chronic and acutecutaneous lupus erythematous with angular cheilitis,oral ulcers, Raynaud phenomenon, and positiveserologies for antinuclear, anticentromere, and anti-Saccharomyces cerevisiae antibodies.