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Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

2021-09Journal article Open access
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dc.contributor.authorBikdeli, Behnood
dc.contributor.authorJiménez, David
dc.contributor.authordel Toro, Jorge
dc.contributor.authorPiazza, Gregory
dc.contributor.authorRivas, Agustina
dc.contributor.authorFernández‐Reyes, José Luis
dc.contributor.authorSampériz, Ángel
dc.contributor.authorOtero, Remedios
dc.contributor.authorSuriñach, José María
dc.contributor.authorSiniscalchi, Carmine
dc.contributor.authorMartín‐Guerra, Javier Miguel
dc.contributor.authorCastro, Joaquín
dc.contributor.authorMuriel, Alfonso
dc.contributor.authorLip, Gregory Y. H.
dc.contributor.authorGoldhaber, Samuel Z.
dc.contributor.authorMonreal, Manuel
dc.contributor.authorMonreal, Manuel
dc.contributor.authorPrandoni, Paolo
dc.contributor.authorBrenner, Benjamin
dc.contributor.authorFarge‐Bancel, Dominique
dc.contributor.authorBarba, Raquel
dc.contributor.authorDi Micco, Pierpaolo
dc.contributor.authorBertoletti, Laurent
dc.contributor.authorSchellong, Sebastian
dc.contributor.authorTzoran, Inna
dc.contributor.authorReis, Abilio
dc.contributor.authorBosevski, Marijan
dc.contributor.authorBounameaux, Henri
dc.contributor.authorMalý, Radovan
dc.contributor.authorVerhamme, Peter
dc.contributor.authorCaprini, Joseph A.
dc.contributor.authorBui, Hanh My
dc.contributor.authorAdarraga, María Dolores
dc.contributor.authorAgud, María
dc.contributor.authorAibar, Jesús
dc.contributor.authorAibar, Miguel Ángel
dc.contributor.authorAmado, Cristina
dc.contributor.authorArcelus, Juan Ignacio
dc.contributor.authorBaeza, Carlos
dc.contributor.authorBallaz, Aitor
dc.contributor.authorBarba, Raquel
dc.contributor.authorBarbagelata, Cristina
dc.contributor.authorBarrón, Manuel
dc.contributor.authorBarrón‐Andrés, Belén
dc.contributor.authorBlanco‐Molina, Ángeles
dc.contributor.authorBotella, Ernesto
dc.contributor.authorCamon, Ana María
dc.contributor.authorCañas, Inmaculada
dc.contributor.authorCasado, Ignacio
dc.contributor.authorCastro, Joaquín
dc.contributor.authorChasco, Leyre
dc.contributor.authorCriado, Juan
dc.contributor.authorde Ancos, Cristina
dc.contributor.authorde Miguel, Javier
dc.contributor.authordel Toro, Jorge
dc.contributor.authorDemelo‐Rodríguez, Pablo
dc.contributor.authorDíaz‐Peromingo, José Antonio
dc.contributor.authorDi Campli, Mario Virgilio
dc.contributor.authorDíez‐Sierra, Javier
dc.contributor.authorDomínguez, Irene Milagros
dc.contributor.authorEscribano, José Carlos
dc.contributor.authorFalgá, Conxita
dc.contributor.authorFarfán‐Sedano, Ana Isabel
dc.contributor.authorFernández‐Capitán, Carmen
dc.contributor.authorFernández‐Reyes, Jose Luis
dc.contributor.authorFidalgo, María Ángeles
dc.contributor.authorFlores, Katia
dc.contributor.authorFont, Carme
dc.contributor.authorFont, Llorenç
dc.contributor.authorFrancisco, Iria
dc.contributor.authorGabara, Cristina
dc.contributor.authorGaleano‐Valle, Francisco
dc.contributor.authorGalindo, David
dc.contributor.authorGarcía, María Angelina
dc.contributor.authorGarcía‐Bragado, Ferrán
dc.contributor.authorGarcía de Herreros, Marta
dc.contributor.authorGarcía‐Hernáez, Raquel
dc.contributor.authorGarcía‐Mullor, María Mar
dc.contributor.authorGarcía‐Raso, Arantxa
dc.contributor.authorGavín‐Sebastián, Olga
dc.contributor.authorGil‐Díaz, Aida
dc.contributor.authorGómez‐Cuervo, Covadonga
dc.contributor.authorGrau, Enric
dc.contributor.authorGuirado, Leticia
dc.contributor.authorGutiérrez, Javier
dc.contributor.authorHernández‐Blasco, Luis
dc.contributor.authorHernando, Elena
dc.contributor.authorHerreros, Miguel
dc.contributor.authorJara‐Palomares, Luis
dc.contributor.authorJaras, María Jesús
dc.contributor.authorJiménez, David
dc.contributor.authorJiménez, Rafael
dc.contributor.authorJoya, Maria Dolores
dc.contributor.authorLeón, José Manuel
dc.contributor.authorLima, Jorge
dc.contributor.authorLlamas, Pilar
dc.contributor.authorLobo, José Luis
dc.contributor.authorLópez‐Jiménez, Luciano
dc.contributor.authorLópez‐Miguel, Patricia
dc.contributor.authorLópez‐Núñez, Juan José
dc.contributor.authorLópez‐Reyes, Raquel
dc.contributor.authorLópez‐Ruiz, Antonio
dc.contributor.authorLópez‐Sáez, Juan Bosco
dc.contributor.authorLorenzo, Alicia
dc.contributor.authorMadridano, Olga
dc.contributor.authorMaestre, Ana
dc.contributor.authorMarchena, Pablo Javier
dc.contributor.authorMartín del Pozo, Mar
dc.contributor.authorMartín‐Guerra, Javier Miguel
dc.contributor.authorMartín‐Martos, Francisco
dc.contributor.authorMella, Carmen
dc.contributor.authorMellado, Meritxell
dc.contributor.authorMercado, Maria Isabel
dc.contributor.authorMoisés, Jorge
dc.contributor.authorMonreal, Manuel
dc.contributor.authordel Valle Morales, María
dc.contributor.authorMuñoz‐Blanco, Arturo
dc.contributor.authorMuñoz‐Rivas, Nuria
dc.contributor.authorNavas, María Sierra
dc.contributor.authorNieto, Jose Antonio
dc.contributor.authorNúñez‐Fernández, Manuel Jesús
dc.contributor.authorObispo, Berta
dc.contributor.authorOlid, Mónica
dc.contributor.authorOlivares, María Carmen
dc.contributor.authorOrcastegui, José Luis
dc.contributor.authorOrtega‐Michel, Clara
dc.contributor.authorOsorio, Jeisson
dc.contributor.authorOtalora, Sonia
dc.contributor.authorOtero, Remedios
dc.contributor.authorParra, Pedro
dc.contributor.authorParra, Virginia
dc.contributor.authorPedrajas, José María
dc.contributor.authorPellejero, Galadriel
dc.contributor.authorPorras, José Antonio
dc.contributor.authorPortillo, José
dc.contributor.authorRiera‐Mestre, Antoni
dc.contributor.authorRivas, Agustina
dc.contributor.authorRivera‐Civico, Francisco
dc.contributor.authorRodríguez‐Chiaradía, Diego Agustín
dc.contributor.authorRodríguez‐Cobo, Ana
dc.contributor.authorRodríguez‐Matute, Consolación
dc.contributor.authorRogado, Jacobo
dc.contributor.authorRoig, Sonia
dc.contributor.authorRosa, Vladimir
dc.contributor.authorRuiz‐Artacho, Pedro
dc.contributor.authorRuiz‐Giménez, Nuria
dc.contributor.authorRuiz‐Ruiz, Justo
dc.contributor.authorRuiz‐Sada, Pablo
dc.contributor.authorSalgueiro, Giorgina
dc.contributor.authorSánchez‐Martínez, Rosario
dc.contributor.authorSánchez‐Muñoz‐Torrero, Juan Francisco
dc.contributor.authorSancho, Teresa
dc.contributor.authorSirisi, Merçe
dc.contributor.authorSoler, Silvia
dc.contributor.authorSuriñach, José María
dc.contributor.authorTirado, Raimundo
dc.contributor.authorTorres, María Isabel
dc.contributor.authorTolosa, Carles
dc.contributor.authorTrujillo‐Santos, Javier
dc.contributor.authorUresandi, Fernando
dc.contributor.authorValero, Beatriz
dc.contributor.authorValle, Reina
dc.contributor.authorVela, Jerónimo Ramón
dc.contributor.authorVidal, Gemma
dc.contributor.authorVillares, Paula
dc.contributor.authorZamora, Carles
dc.contributor.authorGutiérrez, Paula
dc.contributor.authorVázquez, Fernando Javier
dc.contributor.authorEngelen, Matthias
dc.contributor.authorVanassche, Thomas
dc.contributor.authorVerhamme, Peter
dc.contributor.authorHirmerova, Jana
dc.contributor.authorMalý, Radovan
dc.contributor.authorSalgado, Estuardo
dc.contributor.authorAit Abdallah, Nassim
dc.contributor.authorBertoletti, Laurent
dc.contributor.authorBura‐Riviere, Alessandra
dc.contributor.authorCrichi, Benjamin
dc.contributor.authorDebourdeau, Philippe
dc.contributor.authorOlivier, Espitia
dc.contributor.authorFalvo, Nicolas
dc.contributor.authorFarge‐Bancel, Dominique
dc.contributor.authorGalliazzo, Silvia
dc.contributor.authorHelfer, Hélène
dc.contributor.authorMahé, Isabelle
dc.contributor.authorMoustafa, Farès
dc.contributor.authorPoenou, Geraldine
dc.contributor.authorSchellong, Sebastian
dc.contributor.authorBraester, Andrei
dc.contributor.authorBrenner, Benjamin
dc.contributor.authorTzoran, Inna
dc.contributor.authorBilora, Franca
dc.contributor.authorBucherini, Eugenio
dc.contributor.authorCiammaichella, Maurizio
dc.contributor.authorDi Micco, Pierpaolo
dc.contributor.authorImbalzano, Egidio
dc.contributor.authorMaida, Rosa
dc.contributor.authorMastroiacovo, Daniela
dc.contributor.authorPace, Federica
dc.contributor.authorPesavento, Raffaele
dc.contributor.authorPomero, Fulvio
dc.contributor.authorPrandoni, Paolo
dc.contributor.authorQuintavalla, Roberto
dc.contributor.authorRocci, Anna
dc.contributor.authorRomualdi, Roberta
dc.contributor.authorSiniscalchi, Carmine
dc.contributor.authorTufano, Antonella
dc.contributor.authorVisonà, Adriana
dc.contributor.authorZalunardo, Beniamino
dc.contributor.authorGibietis, Valdis
dc.contributor.authorKigitovica, Dana
dc.contributor.authorSkride, Andris
dc.contributor.authorFonseca, Samuel
dc.contributor.authorMartins, Filipa
dc.contributor.authorMeireles, Jose
dc.contributor.authorBosevski, Marijan
dc.contributor.authorBounameaux, Henri
dc.contributor.authorMazzolai, Lucia
dc.contributor.authorBikdeli, Behnood
dc.contributor.authorCaprini, Joseph A.
dc.contributor.authorTafur, Alfonso J.
dc.contributor.authorOchoa‐Chaar, Cassius Iyad
dc.contributor.authorWeinberg, Ido
dc.contributor.authorWilkins, Hannah
dc.contributor.authorBui, Hanh My
dc.date.accessioned2023-10-24T11:34:14Z
dc.date.available2023-10-24T11:34:14Z
dc.date.issued2021-09
dc.description.abstractBackground Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBikdeli B, Jiménez D, Del Toro J, et al. Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism. J Am Heart Assoc. 2021;10(17):e021467. doi:10.1161/JAHA.121.021467pt_PT
dc.identifier.doi10.1161/JAHA.121.021467pt_PT
dc.identifier.issn2047-9980
dc.identifier.urihttp://hdl.handle.net/10400.16/2848
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-Blackwellpt_PT
dc.relation.publisherversionhttps://www.ahajournals.org/doi/full/10.1161/JAHA.121.021467?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectatrial fibrillationpt_PT
dc.subjectmortalitypt_PT
dc.subjectoutcomept_PT
dc.subjectpulmonary embolismpt_PT
dc.titleAssociation Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPagee021467pt_PT
oaire.citation.titleJournal of the American Heart Associationpt_PT
oaire.citation.volume10pt_PT
person.familyNameReis
person.givenNameAbilio
person.identifier.ciencia-idBC10-897E-BE36
person.identifier.orcid0000-0002-9932-3736
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7d29e98e-2f00-4d1f-ad29-8ac1b93bb61d
relation.isAuthorOfPublication.latestForDiscovery7d29e98e-2f00-4d1f-ad29-8ac1b93bb61d

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