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An Immunological Non-responder Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Patient: Considerations About a Clinical Case

2023-04Journal article Open access
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dc.contributor.authorCorreia, Rui
dc.contributor.authorFrança, Margarida
dc.date.accessioned2024-07-02T13:15:29Z
dc.date.available2024-07-02T13:15:29Z
dc.date.issued2023-04
dc.description.abstractHuman immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are two chronic viral infections that share the same mode of transmission, making HIV/HCV coinfection frequent. Highly active antiretroviral therapy (HAART) was a turning point in HIV treatment and has been shown to successfully restore immune function and reduce the frequency of opportunistic infections. Despite a virological response to HAART, a proportion of patients fail to achieve substantial immune recovery, as measured by peripheral CD4 cell counts. Herein, we present the case of a patient with HIV/HCV coinfection who did not achieve successful immune function restoration despite HIV suppression and HCV treatment. Our goal is to promote discussion. Despite considerable advances in the understanding of the impact of HCV on HIV disease progression, there are many individual variables that influence a patient's immune function. In addition, we consider hypogammaglobulinemia as a possible contributor. Further understanding and improvement of immune reconstitution in patients infected with HIV remain an important field of scientific research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares Correia R, França M. An Immunological Non-responder Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Patient: Considerations About a Clinical Case. Cureus. 2023;15(4):e37063. doi:10.7759/cureus.37063pt_PT
dc.identifier.doi10.7759/cureus.37063pt_PT
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.16/2980
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCureus, Inc.pt_PT
dc.relation.publisherversionhttps://doi.org/10.7759/cureus.37063pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectantiretroviral therapypt_PT
dc.subjectco-infectionpt_PT
dc.subjecthepatitis c viruspt_PT
dc.subjecthuman immunodeficiency viruspt_PT
dc.subjectimmunological reconstitution syndromept_PT
dc.titleAn Immunological Non-responder Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Patient: Considerations About a Clinical Casept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPagee37063pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume15pt_PT
person.familyNameCorreia
person.givenNameRui
person.identifier.orcid0000-0002-7452-9818
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication363ac564-7f94-416f-a4ba-eb4d7c4d5208
relation.isAuthorOfPublication.latestForDiscovery363ac564-7f94-416f-a4ba-eb4d7c4d5208

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