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Living Donors’ Age Modifies the Impact of Pre-Donation Estimated Glomerular Filtration Rate on Graft Survival

2023-10Journal article Open access
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dc.contributor.authorAlmeida, Manuela
dc.contributor.authorRibeiro, Catarina
dc.contributor.authorSilvano, José
dc.contributor.authorPedroso, Sofia
dc.contributor.authorTafulo, Sandra
dc.contributor.authorMartins, La Salete
dc.contributor.authorRamos, Miguel
dc.contributor.authorJ, Malheiro
dc.date.accessioned2024-07-04T11:17:42Z
dc.date.available2024-07-04T11:17:42Z
dc.date.issued2023-10
dc.description.abstractBackground: The global scarcity of organs for kidney transplants (KTs) has led to the increased acceptance of living donors (LDs) with minor abnormalities to increase the donor pool.. We sought to evaluate the effects of some of these LDs' clinical characteristics (older age, borderline renal function, hypertension, dyslipidemia, smoking, and obesity) on graft outcomes. Methods: We studied 352 recipients of LDKTs (1998-2020). Firstly, considering the recipients and KT variables, we identified relevant predictors of overall and censored graft failure (GF). Then, adjusting for these predictors, we explored LD variables as predictors of overall and censored GF in a multivariable Cox model. Results: The recipients from LD with higher eGFR (≥90 mL/min/1.73 m2) had significantly better overall and censored graft survival GS) at 15 y after KT (respectively, 67 and 75% vs. 46 and 46%, p < 0.001). Importantly, none of the remaining LD factors which were evaluated (hypertension, dyslipidemia, smoking, proteinuria, and obesity) were independent predictors of GF. In recipients from LDs < 50 y, having an eGFR < 90 was an independent predictor of overall GF [adjusted HR (95%CI) of 2.578 (1.120-5.795)] and censored GF [adjusted HR (95%CI) of 3.216 (1.300-7.959)], compared to recipients from LDs with eGFR ≥ 90. Contrarily, when donors were older, no difference in the risk of GF was observed between eGFR categories. Conclusion: In our cohort, lower pre-donation eGFR had an impact on GS only in younger LDs. An age-adjusted eGFR cutoff may be pursued for improved donor admissibility.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida M, Ribeiro C, Silvano J, et al. Living Donors' Age Modifies the Impact of Pre-Donation Estimated Glomerular Filtration Rate on Graft Survival. J Clin Med. 2023;12(21):6777. doi:10.3390/jcm12216777pt_PT
dc.identifier.doi10.3390/jcm12216777pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.16/2996
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.publisherversionhttps://doi.org/10.3390/jcm12216777pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectagept_PT
dc.subjectglomerular filtration ratept_PT
dc.subjectgraft survivalpt_PT
dc.subjectkidney transplantationpt_PT
dc.subjectliving donorpt_PT
dc.subjectmedically complex living donorspt_PT
dc.titleLiving Donors’ Age Modifies the Impact of Pre-Donation Estimated Glomerular Filtration Rate on Graft Survivalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue21pt_PT
oaire.citation.startPage6777pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNamealmeida
person.familyNameSilvano
person.familyNamePedroso
person.familyNameTafulo
person.familyNameMartins
person.familyNameMalheiro
person.givenNamemanuela
person.givenNameJosé
person.givenNameSofia
person.givenNameSandra
person.givenNameLa Salete
person.givenNameJorge
person.identifier1861404
person.identifier1911437
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person.identifier.ciencia-id5A13-E9F2-E5C7
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person.identifier.ciencia-id7A1B-8631-FC46
person.identifier.orcid0000-0002-0312-3685
person.identifier.orcid0000-0002-5266-2300
person.identifier.orcid0000-0002-8539-906X
person.identifier.orcid0000-0002-3911-0245
person.identifier.orcid0000-0002-6110-2102
person.identifier.orcid0000-0002-9625-5889
person.identifier.ridK-6320-2013
person.identifier.scopus-author-id56207848700
person.identifier.scopus-author-id26434404600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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