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IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch

2021Journal article Open access
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dc.contributor.authorAbreu, Maria
dc.contributor.authorMiranda, Marta
dc.contributor.authorCastro, M
dc.contributor.authorFernandes, Iolanda
dc.contributor.authorCabral, Renata
dc.contributor.authorSantos, Ana Helena
dc.contributor.authorFonseca, Sonia
dc.contributor.authorRodrigues, João
dc.contributor.authorLeander, Magdalena
dc.contributor.authorLau, Catarina
dc.contributor.authorFreitas, Inês
dc.contributor.authorCoimbra, Susana
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorLima, Margarida
dc.date.accessioned2022-11-07T14:04:33Z
dc.date.accessioned2022-11-07T14:04:34Z
dc.date.available2022-11-07T14:04:33Z
dc.date.available2022-11-07T14:04:34Z
dc.date.issued2021
dc.description.abstractThe itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients with CTCL (17 MF and 10 SS) and 29 controls (blood donors) were analyzed for interleukin- (IL-) 31 and IL-8; correlations with disease and itch severity were evaluated. IL-31 serum levels were higher in CTCL patients than in controls and higher in SS than in MF. Also, serum IL-31 levels were higher in patients with advanced disease compared to those with early disease, and they correlated positively with lactate dehydrogenase and beta 2-microglobulin levels, as well as with the Sézary cell count. Itch affected 67% of CTCL patients (MF: 47%; SS: 100%). Serum IL-31 levels were higher in itching patients than in controls and in patients without itching. There was no association between serum IL-8 and disease severity, nor with itching. Serum IL-8 levels correlated positively with peripheral blood leukocyte and neutrophil counts in CTCL patients. Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigationpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAbreu M, Miranda M, Castro M, et al. IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch. Adv Hematol. 2021;2021:5582581. Published 2021 Jul 20. doi:10.1155/2021/5582581pt_PT
dc.identifier.doi10.1155/2021/5582581pt_PT
dc.identifier.issn1687-9112
dc.identifier.issn1687-9104
dc.identifier.urihttp://hdl.handle.net/10400.16/2738
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Pub. Corppt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relation.publisherversionhttps://www.hindawi.com/journals/ah/2021/5582581/#abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleIL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itchpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.startPage5582581pt_PT
oaire.citation.titleAdvances in Hematologypt_PT
oaire.citation.volume2021pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePimenta de Castro
person.familyNameFernandes
person.familyNameCabral
person.familyNameSantos
person.familyNameFonseca
person.familyNameRodrigues
person.familyNameLeander
person.familyNameLau
person.familyNameFreitas
person.familyNameMeireles Coimbra
person.familyNameSantos-Silva
person.familyNameLima
person.givenNameMafalda
person.givenNameIolanda
person.givenNameRenata
person.givenNameAna Helena
person.givenNameSonia
person.givenNameJoão
person.givenNameMagdalena
person.givenNameCatarina
person.givenNameInês
person.givenNameCarla Susana
person.givenNameAlice
person.givenNameMargarida
person.identifier.ciencia-id7913-2B7A-456B
person.identifier.ciencia-id0313-EA1F-E29C
person.identifier.ciencia-id1818-39C9-ECC9
person.identifier.ciencia-id3A11-3945-4DC4
person.identifier.ciencia-id8410-F6C9-183F
person.identifier.orcid0000-0003-0721-6077
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person.identifier.orcid0000-0001-9881-7104
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person.identifier.orcid0000-0001-9152-8844
person.identifier.orcid0000-0002-3050-2672
person.identifier.orcid0000-0001-8284-0588
person.identifier.orcid0000-0002-8806-2489
person.identifier.orcid0000-0001-8411-8038
person.identifier.orcid0000-0002-2565-3169
person.identifier.orcid0000-0001-9702-5260
person.identifier.ridK-2326-2013
person.identifier.ridS-7466-2016
person.identifier.scopus-author-id6603836490
person.identifier.scopus-author-id7202143317
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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