Repository logo
 
Publication

Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient

dc.contributor.authorVentura Aguiar, P.
dc.contributor.authorDias, C.
dc.contributor.authorAzevedo, P.
dc.contributor.authorSilva, H.
dc.contributor.authorAlmeida, M.
dc.contributor.authorPedroso, S.
dc.contributor.authorMartins, L.
dc.contributor.authorDias, L.
dc.contributor.authorRodrigues, A.
dc.contributor.authorViscaíño, R.
dc.contributor.authorCabrita, A.
dc.contributor.authorHenriques, A.
dc.date.accessioned2016-08-01T10:54:33Z
dc.date.available2016-08-01T10:54:33Z
dc.date.issued2015-07
dc.description.abstractBACKGROUND: Histiocytic sarcoma (HS) is a rare hematologic neoplasm with a few hundred cases having been described to date.pt_PT
dc.description.abstractCASE PRESENTATION: We report the case of a 56-year-old woman with a history of hepatitis C infection and chronic kidney disease (CKD), submitted to a kidney transplant in 1984, under maintenance immunosuppression with prednisone and azathioprine. Patient presented with a relentlessly growing mass on her right front thorax. It was painless, smooth, and adherent to the deep muscle. Laboratory studies were unremarkable. Ultrasonography and computerized tomography (CT) scan revealed a highly vascularized heterogeneous mass (8×9 cm), with a necrotic centre. Positron emission tomography (PET) scan demonstrated multiple thoracic, abdominal, and pelvic nodules. Histology revealed a highly undifferentiated HS (vimentin, CD68, CD99, and CD4 positive). In spite of having started treatment with etoposide and thalidomide, no clinical response was achieved and the patient died three months later.pt_PT
dc.description.abstractCONCLUSIONS: To the authors' knowledge, this is the first described case of HS in a solid organ transplant patient.pt_PT
dc.identifier.citationJ Nephropathol. 2015 Jul;4(3):97-100.pt_PT
dc.identifier.doi10.12860/jnp.2015.18pt_PT
dc.identifier.issn2251-8363
dc.identifier.urihttp://hdl.handle.net/10400.16/1988
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociety of Diabetic Nephropathy Preventionpt_PT
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544561/pdf/JNP-4-97.pdfpt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectHistiocytic sarcomapt_PT
dc.subjectMalignancypt_PT
dc.subjectPost-transplant lymphoproliferative diseasept_PT
dc.subjectTransplantpt_PT
dc.titleHistiocytic sarcoma; case report of a rare disease in a kidney transplant recipientpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceIranpt_PT
oaire.citation.endPage100pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage97pt_PT
oaire.citation.titleJournal of Nephropathologypt_PT
oaire.citation.volume4pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Histiocytic sarcoma;.pdf
Size:
987.47 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.35 KB
Format:
Item-specific license agreed upon to submission
Description: