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Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman

2019Journal article Open access
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dc.contributor.authorGuerreiro, I.
dc.contributor.authorVieira, C.
dc.contributor.authorSoares, A.
dc.contributor.authorBraga, A.
dc.contributor.authorJácome, M.
dc.contributor.authorDinis, J.
dc.date.accessioned2020-05-05T13:51:41Z
dc.date.available2020-05-05T13:51:41Z
dc.date.issued2019
dc.description.abstractEsthesioneuroblastoma (ENB) is a rare malignant tumor that commonly develops in the upper nasal cavity. Standard treatment is not established, especially in locally advanced disease which portends the worse prognosis. Hereby, we report a case of a 27-year-old, 23-week pregnant woman, with a 2-month history of progressively growing right cervical lymphadenopathy, nasal obstruction, anosmia, frequent episodes of epistaxis, and right frontal headache. Imagiological evaluation revealed a lesion with 7×5,2×3,2 cm in the nasal fossae with extension to the ethmoidal complex and right olfactive fend and invasion of the endocranial compartment associated with lymphadenopathy. The biopsy revealed a high-grade EBN. Neoadjuvant chemotherapy with cisplatin and etoposide was administrated during pregnancy and continued after delivery up to 6 cycles of treatment with partial response. Radiotherapy followed, with complete response. This case report is intended to highlight that a high grade of suspicion should be kept in the presence of nonspecific symptoms of nasal obstruction, anosmia, facial pain, and/or headache and focus that chemotherapy is an important component of a combined-treatment modality for locally advanced ENB that can be used during pregnancy in a lifesaving situation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGuerreiro IM, Vieira C, Soares A, Braga A, Jácome M, Dinis J. Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman. Case Rep Oncol Med. 2019;2019:3789317. Published 2019 Aug 19. doi:10.1155/2019/3789317pt_PT
dc.identifier.doi10.1155/2019/3789317pt_PT
dc.identifier.issn2090-6706
dc.identifier.issn2090-6714
dc.identifier.urihttp://hdl.handle.net/10400.16/2362
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/crionm/2019/3789317/pt_PT
dc.titleManagement of Locally Advanced Esthesioneuroblastoma in a Pregnant Womanpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.startPage3789317pt_PT
oaire.citation.titleCase reports in oncological medicinept_PT
oaire.citation.volume2019pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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