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Long-Term Complications After Renal Transplantation
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Abstract(s)
IN the past, every effort was directed at the prevention of
acute rejection in renal transplant (RT) patients (pts).
Ever since the introduction of the new immunosuppressive
agents in the late 1990s, the short-term results of renal graft
survival are considered satisfactory. In recent years, the
prevention of long-term graft loss and the extension of life
expectancy have gained new emphasis. The immunosuppressive
agents though, namely calcineurin-inhibitors and
steroids, may potentiate the development of several problems
in RT pts: obesity, hyperglycemia, hyperlipidemia, and
hypertension,1 which are not only risk factors for cardiovascular
disease but also for graft loss.2,3
We performed a retrospective analysis of all RTs performed
at our unit that reached 10 years (y) with a
functioning graft. The aim of the study was to evaluate
long-term complications and, in view of the results, to seek
a possible strategy that minimizes these problems.
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Publisher
Elsevier