Publication
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection
dc.contributor.author | Cardoso, R. | |
dc.contributor.author | Lacerda, P. | |
dc.contributor.author | Costa, P. | |
dc.contributor.author | Machado, A. | |
dc.contributor.author | Carvalho, A. | |
dc.contributor.author | Bordalo, A. | |
dc.contributor.author | Fernandes, R. | |
dc.contributor.author | Soares, R. | |
dc.contributor.author | Richter, J. | |
dc.contributor.author | Alves, H. | |
dc.contributor.author | Botelho, M. | |
dc.date.accessioned | 2018-07-05T13:24:47Z | |
dc.date.available | 2018-07-05T13:24:47Z | |
dc.date.issued | 2017-11-28 | |
dc.description.abstract | Schistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These estrogenic molecules are metabolized to active quinones that induce modifications in DNA. The cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases involved in estrogen biosynthesis and metabolism, the generation of DNA damaging procarcinogens, and the response to anti-estrogen therapies. IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in various tissues. This cytokine is largely expressed in the female urogenital tract as well as reproductive organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance. In the present study, we investigated the polymorphic variants in the CYP2D6 gene and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium-infected children patients from Guine Bissau. CYP2D6 inactivated alleles (28.5%) and IL6G-174C (13.3%) variants were frequent in S. haematobium-infected patients when compared to previously studied healthy populations (4.5% and 0.05%, respectively). Here we discuss our recent findings on these polymorphisms and whether they can be predictive markers of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Int J Mol Sci. 2017 Nov 28;18(12). pii: E2560 | pt_PT |
dc.identifier.doi | 10.3390/ijms18122560 | pt_PT |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10400.16/2198 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | MDPI | pt_PT |
dc.relation.publisherversion | http://www.mdpi.com/1422-0067/18/12/2560 | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | BMI | pt_PT |
dc.subject | S. haematobium-associated bladder cancer | pt_PT |
dc.subject | estrogen biosynthesis | pt_PT |
dc.subject | estrogen metabolism | pt_PT |
dc.title | Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.conferencePlace | Switzerland | pt_PT |
oaire.citation.issue | 12 | pt_PT |
oaire.citation.startPage | 2560 | pt_PT |
oaire.citation.title | International Journal of Molecular Sciences | pt_PT |
oaire.citation.volume | 18 | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |