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Evaluation of effluent markers cancer antigen 125, vascular endothelial growth factor, and interleukin‐6: relationship with peritoneal transport

2004Journal article Open access
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dc.contributor.authorRodrigues, Anabela
dc.contributor.authorMartins, M.
dc.contributor.authorSantos, M.
dc.contributor.authorFonseca, Isabel
dc.contributor.authorCarlos Oliveira, JosĂŠ
dc.contributor.authorCabrita, A.
dc.contributor.authorCastro e Melo, J.
dc.contributor.authorKrediet, R.
dc.date.accessioned2010-07-29T16:57:28Z
dc.date.available2010-07-29T16:57:28Z
dc.date.issued2004
dc.descriptionO pdf deste artigo (p. 8-12) contĂŠm mais 2 artigos relacionados:(p. 2-7) e (p. 13-17)pt
dc.description.abstractPeritoneal hyperpermeability has been associated with increased levels of effluent vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Mesothelial cells can produce various vasoactive substances besides VEGF. A large mesothelial mass may possibly lead to high dialysate VEGF concentrations and may partly explain some cases of peritoneal hyperpermeability during a patient’s early months on peritoneal dialysis (PD). Early peritoneal fast transport may therefore not necessarily be associated with systemic inflammation. To investigate the relationship of effluent markers and peritoneal transport, we measured the appearance rates of cancer antigen 125 (CA125), VEGF, and IL-6 in 4-hour effluents from 69 peritoneal equilibration tests (PETs) using 3.86% glucose solution. At the same time, we measured serum VEGF and IL-6. Our analyses included an early group (EG), whose members had been on PD for 4.6 ± 3.3 months, and a later group (LG), whose members had been on PD for 30 ± 17 months. In EG, dialysate-to-plasma creatinine at 4 hours (D/PCr240) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6. The values of CA125/min and VEGF/min also correlated (r = 0.40, p = 0.034). Fast transporters in EG had higher effluent CA125 (p = 0.057) and VEGF (p = 0.0001), but not serum or effluent IL-6. In LG, D/PCr240 again correlated significantly with dialysate VEGF(r = 0.51, p = 0.009), but not with CA125. Fast transporters in LG tended to have higher levels of serum and effluent IL-6 and effluent VEGF. We conclude that fast solute transport rates at the beginning of PD are associated with signs of a large mesothelial cell mass and not consistently associated with higher systemic IL-6. The VEGF produced by mesothelial cells can mediate early peritoneal hyperpermeability in some populations. Later, mesothelial mass is lost and is no longer related to increased intraperitoneal VEGF or IL-6.pt
dc.identifier.citationAdv Perit Dial. 2004; 20:8‐12. PMID: 15384786pt
dc.identifier.issn1197-8554
dc.identifier.urihttp://hdl.handle.net/10400.16/347
dc.language.isoengpt
dc.publisherPeritoneal Dialysis Bulletin, Inc.pt
dc.relation.publisherversionhttp://www.advancesinpd.com/pt
dc.subjectPeritoneal transportpt
dc.subjectmesothelial cellspt
dc.subjectvascular endothelialpt
dc.subjectgrowth factorpt
dc.subjectcancer antigen 125pt
dc.subjectinterleukin-6pt
dc.titleEvaluation of effluent markers cancer antigen 125, vascular endothelial growth factor, and interleukin‐6: relationship with peritoneal transportpt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCanadapt
oaire.citation.endPage12pt
oaire.citation.startPage8pt
oaire.citation.titleAdvances in Peritoneal Dialysispt
person.familyNameSoares Rodrigues
person.familyNameFonseca
person.familyNameOliveira
person.givenNameAnabela
person.givenNameIsabel
person.givenNameJosĂŠ Carlos
person.identifier415128
person.identifier806053
person.identifier.ciencia-id651F-A9D2-2136
person.identifier.ciencia-id6716-A5D1-FB3F
person.identifier.ciencia-id801F-D4FE-8694
person.identifier.orcid0000-0001-8818-2141
person.identifier.orcid0000-0001-8984-1751
person.identifier.orcid0000-0003-2142-6839
person.identifier.ridK-5226-2013
person.identifier.ridK-6339-2013
person.identifier.scopus-author-id7202269896
person.identifier.scopus-author-id55941495000
rcaap.rightsopenAccesspt
rcaap.typearticlept
relation.isAuthorOfPublication2276a1c5-40fe-41e9-a369-a40049bf81e3
relation.isAuthorOfPublication2c7a2607-6376-486e-9ad5-490d0032946c
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relation.isAuthorOfPublication.latestForDiscovery2276a1c5-40fe-41e9-a369-a40049bf81e3

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